Received: 18 December 2017 Revised: 16 April 2018 Accepted: 14 May 2018 DOI: 10.1002/jclp.22651 RESEARCH ARTICLE Examining the effectiveness of an intensive, 2-week treatment program for military personnel and veterans with PTSD: Results of a pilot, open-label, prospective cohort trial Craig J. Bryan Feea R. Leifker David C. Rozek AnnaBelle O. Bryan Mira L. Reynolds D. Nicolas Oakey Erika Roberge National Center for Veterans Studies, The University of Utah Correspondence Craig J. Bryan, PsyD, ABPP, National Center for Veterans Studies, 332 S 1400 E, Room 4, Salt Lake City, UT 84112. Email: craig.bryan@utah.edu Abstract Objective This study aimed to examine the effectiveness of cognitive processing therapy (CPT) for posttraumatic stress disorder (PTSD) when administered on a daily basis during a 2-week period of time. Method In an open-label, prospective cohort pilot trial, 20 U.S. military personnel and veterans diagnosed with PTSD or sub- threshold PTSD participated in 12 daily sessions of CPT. Pri- mary outcomes included Clinician Administered PTSD Scale for DSM-5 and PTSD Checklist for DSM-5 scores. Secondary out- comes included Patient Health Questionnaire-8 and Beck Scale for Suicide Ideation (BSSI) scores. Interviews and self-report scales were completed at pretreatment, posttreatment, and 6 months after the treatment. Results Relative to baseline, PTSD symptom severity and rates of PTSD diagnosis were significantly reduced at posttreatment and 6- month follow-up. Depression symptom severity did not significantly improve, but suicide ideation significantly decreased at 6-month follow-up. Conclusions Daily administration of CPT is associated with signifi- cant reductions in PTSD and suicide ideation. KEYWORDS cognitive processing therapy, military, posttraumatic stress disorder, psychotherapy, veteran J. Clin. Psychol. 2018;1–12. wileyonlinelibrary.com/journal/jclp c  2018 Wiley Periodicals, Inc. 1