International Journal of Research in Medical Sciences | November 2021 | Vol 9 | Issue 11 Page 3289 International Journal of Research in Medical Sciences Kumar R et al. Int J Res Med Sci. 2021 Nov;9(11):3289-3297 www.msjonline.org pISSN 2320-6071 | eISSN 2320-6012 Original Research Article Evaluating effects of allo-vedic preparation Raj Nirwan Bati on symptomatic cases of COVID-19 at a tertiary level health care facility in rural setting of northern India Raj Kumar 1 , Ramakant Yadav 2 , Ramakant Rawat 3 , Naresh P. Singh 4 *, Indra K. Sharma 5 , Prashant Yadav 6 INTRODUCTION The year 2020 became the most challenging year, specifically, for the fraternity of medical field in purview of the present pandemic of corona virus disease 2019 (COVID-19). From the Ayurvedic point of view, COVID- 19 is a janapadodhwansa vikara (epidemic disease). Janapadodhwansa is a situation where the environment - air, water, land and seasons - is vitiated, causing a simultaneous manifestation of a disease among large 1 Department of Neurosurgery, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India 2 Department of Neurology, 3 Department of Internal Medicine, 4 Department of Community Medicine, 5 Department of Pediatrics, 6 Department of Respiratory Medicine, Uttar Pradesh University of Medical Sciences, Saifai, Etawah, Uttar Pradesh, India Received: 15 September 2021 Revised: 08 October 2021 Accepted: 12 October 2021 *Correspondence: Dr. Naresh P. Singh, E-mail: nareshpalsingh@gmail.com Copyright: © the author(s), publisher and licensee Medip Academy. This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. ABSTRACT Background: The present pandemic of COVID-19 has created a huge pressure on the current health system of the world as the burden is increasing exponentially day by day. Study evaluated the effect of the novel allo-vedic formulation named Raj Nirwan Bati (RNB) on the clinical symptoms, microbiological, bio-chemical, haematological and radiological profile of patients of COVID-19. Methods: Prospective single arm, non- randomized clinical trial was conducted which enrolled 40 reverse transcriptase- polymerase chain reaction (RT-PCR) confirmed patients of severe acute respiratory syndrome corona virus-2 (SARS- CoV-2). Each patient was given one dosage of RNB twice a day for 10 days. Patients were evaluated on the clinical symptoms, microbiological, bio-chemical, haematological and radiological profile of patients of COVID-19. Cochran’s Q tests was used to assess statistical significance. Results: The study revealed that 31 (77.5%) of the COVID-19 cases were having mild, 6 (15%) moderate and 3 (7.5%) having severe form of illness. The association between absence of clinical symptom (fever, cough, breathlessness, sore throat, fatigue and myalgia) and the day of evaluation (first, fifth and tenth day) after start of RNB intervention was found to be statistically significant (p<0.001, p<0.001, p=0.002, p<0.001, p<0.001 and p<0.001) respectively. Thirty (75.0%) of the cases on RNB intervention became negative for SARS-CoV-2 after day 5 on naso-pharyngeal and oro- pharyngeal RT-PCR testing (p<0.001). Statistically significant association was observed only for changes in proportion of cases with elevated lactate dehydrogenase (LDH) values and C-reactive protein (CRP) positive from day 1 to day 10 of RNB intervention (p<0.001). Conclusions: RNB may be considered a drug to fight against COVID-19. Keywords: COVID-19, Ayurvedic medicine, SARS-CoV-2, RT-PCR DOI: https://dx.doi.org/10.18203/2320-6012.ijrms20214411