Abstracts / Drug and Alcohol Dependence 171 (2017) e2–e226 e143 Initial subjective favorability moderates the relationship between false harm beliefs and daily consumption of reduced nicotine content cigarettes Melissa Mercincavage * , Megan L. Saddleson, Andrew Strasser Center for Interdisciplinary Research on Nicotine Addiction and Tobacco Center of Regulatory Science, University of Pennsylvania, Philadelphia, PA, United States Aims: To determine if product beliefs resulting from viewing an advertisement for reduced nicotine content (RNC) cigarettes affect subsequent use behaviors, and if initial subjective ratings moderate these effects. We hypothesized that false beliefs would increase smoking behaviors, and that this relationship would be stronger among smokers with favorable (vs. negative) initial sub- jective responses to RNC cigarettes. Methods: Data were taken from 77 non-treatment-seeking daily smokers (66.2% male) participating in a randomized con- trolled trial of RNC cigarette effects on use behaviors and harm exposure. After viewing an RNC cigarette advertisement and smok- ing their preferred cigarette brand for 5 days, smokers then used RNC cigarettes for 10 days. Smokers self-reported daily cigarette consumption, collected spent filters, and provided topography assessments every 5 days. Results: Stepwise regression analyses found that false beliefs did not affect smoking behaviors (p’s = 0.07–0.49), but subjec- tive ratings moderated the association of false beliefs with daily cigarette consumption (B = 0.18, SE = 0.06, p = 0.005). Among smokers with favorable initial subjective responses, false beliefs increased daily consumption of RNC cigarettes. Conclusions: Initial subjective responses to RNC cigarettes have important implications for understanding how false beliefs about product risks are associated with subsequent use. These findings are important for determining how to communicate risks of RNC cigarette use; such efforts may need to account for subjective prod- uct responses to fully evaluate the impact of disseminating this information. Financial support: This work was supported by the National Institutes of Health (NIH) and FDA Center for Tobacco Products (R01 CA120594; P50 CA179546). The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH or FDA. http://dx.doi.org/10.1016/j.drugalcdep.2016.08.395 High-risk behaviors among Iranian female drug users inspiring health belief model Effat Merghati-khoei 1,* , Mansoreh jamshidimanesh 1 , Ilika Fariba Ilika 1 , Mostafa Hosseini 2 1 Iranian National Center for Addiction Studies, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran 2 Epidemiology, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran Aims: The relationship between drug abuse and risky sexual behaviors is well documented. Sexually transmitted infections are a health crisis among Iranian drug using women, who experience higher rates of morbidity than their male counterparts. There are limited interventions that help to prevent risky sexual behaviors, promote self-efficacy and reduce STIs HIV within Iranian drug abus- ing populations. We intend to explore the efficacy of gender specific education based on the health belief model in this study. Methods: In this experimental study we recruited 106 drug using women aged 18 and above; and sexually active. Women were recruited from Drop-In-Centers in Tehran. Women were randomly allocated to intervention group (n = 53) who received a gender spe- cific education inspiring HBM (4 sessions) and control group (n = 53) received one session health education relevant to STIs HIV pre- vention. We collected data using a valid structured questionnaire at baseline and 2 month follow up. Descriptive analytical tests including t-test, logistic regression analysis, and Pearson correla- tion Mean, ANCOVA analysis were employed to analyze the data. Results: Mean age of women in the intervention arm (35.3 ± 7.4) and control (36.2 ± 8.3) did not show significant difference. The mean score of intervention group in knowledge and attitude (p < .0001), perceived susceptibility (p < .0001), perceived bene- fits (p = .001), perceived barriers (p < .0001), perceived selfefficacy (p < .0001) were significantly greater than those in control group. Conclusions: Our results suggest that the gender specific edu- cation is effiecient in reduction of the participants’ risky sexual behaviors by promoting their self-efficacy. This information will be critically useful in guiding in gender sensitive prevention and treatments for future patients with risky sexual behaviors as well as drug using women at risk of sexual transmitted infections. Financial support: This project was supported by Tehran Uni- versity of Medical Sciences. http://dx.doi.org/10.1016/j.drugalcdep.2016.08.396 Sexual and drug use risk behaviors and HIV- and Hepatitis-C transmission knowledge among non-treatment-seeking individuals with opioid use disorders in NYC Verena Metz 1,2,* , Maria Sullivan 1,2,3 , Jermaine D. Jones 1,2 , Elizabeth Evans 1,2 , Rachel Luba 1,2 , Jonathan Vogelman 1,2 , Sandra Comer 1,2 1 New York State Psychiatric Institute, New York, NY, United States 2 Columbia University Medical Center, New York, NY, United States 3 Alkermes, Inc, Waltham, MA, United States Aims: To identify different subgroups of non-treatment-seeking individuals with opioid use disorders (OUDs) in NYC. Methods: Opioid users who screened for research studies at the Substance Use Research Center in the New York State Psychiatric Institute were administered a locally developed questionnaire on their current and past drug use and sexual risk behaviors, their HIV- and Hepatitis-C transmission and prevention knowledge, and their preferences in regard to risk behavior interventions. Results: Over the course of 1.5 years, 138 adults with OUDs (24 female, 114 male) with a mean age of 46.5 years (SD = 9.5) were assessed. SPSS was used to conduct ANOVAs for between-group differences in continuous variables and Chi-square tests in cate- gorical variables. Analyses revealed significant differences between the 3 main ethnic subgroups (n = 65 African Americans, n = 34 His- panics, n = 31 Whites). Compared to the African American (AA) and Hispanic (H) individuals, Whites (W) were the youngest (mean age (years): W 38.8 (SD = 9.7), AA 50.5 (SD = 8.7), H 46.3 (SD = 6.6), p < 0.01), the heaviest cigarette smokers (mean cigarettes/day: W 14.3 (SD = 9.9), AA 6.4 (SD = 5.4), H 11.7 (SD = 10.1), p < 0.01), and most frequently injecting their opioids (IDUs: W 73.3%, AA 13.8%,