*Corresponding Author: Shankul Kumar, Email: Kumar.sankul@gmail.com, Phone No: +91-9978242498 ISSN 0976 – 3333 ORIGINAL RESEARCH ARTICLE Available Online at www.ijpba.info International Journal of Pharmaceutical & Biological Archives 2012; 3(4):853-857 Comparative Antidiabetic Studies of Leaves of Ipomoea carnea and Grewia asiatica on Streptozotocin Induced Diabetic Rats Kadiyawala Abdul Latif .A*, A K Prasad, Shankul kumar, Satish V Iyer, Hitesh A Patel, Jatin A Patel G.H.B. College of Pharmacy, Aniyad, Gujarat, India Received 09 May 2012; Revised 07 Aug 2012; Accepted 15 Aug 2012 ABSTRACT The plants Ipomoea carnea and Grewia asiatica are ethnobotanically used in the treatment of various diseases including diabetes and heart diseases. Diabetes mellitus is a disease characterized by hyperglycaemia, and hyperlipidaemia which leads to an increased risk of atherosclerosis and other cardiovascular diseases. The leaves of Ipomoea carnea and Grewia Asiatica was shade dried and powdered. It was subjected to extraction with water . The aqueous extracts of both leaves were administered orally at two different doses of 250mg/kg and 500mg/kg. In the present study the hypoglycaemic and antihyperglycemic property of Ipomoea carnea leaves and Grewia asiatica leaves was carried out in normal rats, and in streptozotocin (50mg/kg.i.p) induced diabetic rats. In addition, the plant extract was evaluated by oral glucose tolerance test (OGTT) model for their influence at different doses on blood glucose levels in normal rats fed with overload of glucose. Glibenclamide (10mg/kg p.o) was used as a reference drug for antihyperglycemic activity. The interpretation of the results was done after subjecting the data obtained from various studies to statistical analysis which included one way ANOVA followed by post tests like Dunnet‘t’. Oral admisntration of Ipomoea carnea leaves and Grewia asiatica leaves for 21 days significantly reduced blood glucose level in STZ induced diabetic rats. Key words: Hyperglycaemia, Hyperlipidaemia, Streptozotocin, and Glibenclamide. INTRODUCTION Diabetes mellitus (DM) is a very anciently-known disease of mankind. This disease was known to Indian and Arabian physicians some 5,000 years ago. Sushuruta, the great ancient Indian physician, in his treatise has mentioned not only this disease but also its symptomatology, etiology and classification which hold good even today, in spite of great advances in the field of medicine. It is he who first detected that the taste of the urine of a diabetic is sweet and coined the name for the disease as ‘Madhu Meha’ Similarly in Latin, this disease is called Diabetes Mellitus.‘Diabetes’ means siphoning out and ‘mellitus’ means honey. Diabetes mellitus is a complex syndrome that affects multiple organ systems. There is still much to learn about the diabetes mellitus [1-3] Diabetes mellitus (DM) is one such type which is a major health problem around the globe in recent time, Asia and Africa are the most viable areas where the disease is feared to raise 2-3 folds. DM is a metabolic disorder characterized by hyperglycemia with impairment of carbohydrate, fat and protein metabolism . [4-6] Hyperglycemic condition causes increase glycosylation leading to biochemical and morphological abnormalities due to altered protein structure which over a period of time develops diabetic complications such as nephropathy, retinopathy, neuropathy and cardiomyopathy. Traditional medicine derived mainly from plants play major role in the management of diabetes mellitus . [7-8] World health organization (WHO) has recommended the evaluation of traditional plant treatments for diabetes as they are effective, non- toxic, with less or no side effect and are considered to be excellent candidates for oral therapy. Recently there are many medicinal plants possessing experimental and clinical antidiabetic activity that have been used in traditional systems of medicine . [9-10] .