~ 24 ~ International Journal of Clinical Obstetrics and Gynaecology 2022; 6(5): 24-31 ISSN (P): 2522-6614 ISSN (E): 2522-6622 © Gynaecology Journal www.gynaecologyjournal.com 2022; 6(5): 24-31 Received: 01-07-2022 Accepted: 05-08-2022 Affiliation all author is given at the end of references section Corresponding Author: Anish Desai Clinical Pharmacologist and Pharmaceutical Physician, Director, Intellimed Healthcare Solutions, Mumbai, Maharashtra, India Expert consensus on the role of nutraceuticals in women’s health: Menarche to menopause Anahita Chauhan, Hemant Thacker, Ashwini Bhalerao Gandhi, Ritu Khanna, PM Gopinath, Kiran Coelho, Nayna Patel, Kamini Patel, Rohit Gutgutia, Srilatha Gorthi, Abhilasha Chaturvedi, Meenakshi Ahuja, Kanika Jain, Sunita Chandra and Anish Desai DOI: https://doi.org/10.33545/gynae.2022.v6.i5a.1206 Abstract Throughout life, Women get affected by one or more disorders–dysmenorrhea (young adults), premenstrual syndrome, mastalgia, infertility (reproductive age group), and menopausal symptoms (menopause phase). Although guidelines for these disorders recommend standard drugs, the scientific literature supports the evidence-based use of nutraceuticals. In addition, as life expectancy is rising, there is a renewed focus on nutraceuticals for health and well-being (extending health span, not just lifespan). A group of gynecology experts came together to help leverage the benefits of nutritional science. Their discussion based on peer- reviewed data and clinical experience led to a consensus document on nutraceuticals for women's health. They recommend the use of nutraceuticals for different gynecological disorders. The supporting data and consensus statements will guide clinicians to use nutraceuticals to enhance the health and well-being of women. Keywords: Dietary supplements, evening primrose oil, amino acids, branched-chain amino acids, cod liver oil, coenzyme Q10 1. Introduction In a fast-paced VUCA (volatile, uncertain, complex, and ambiguous) world, quick fixes to problems are often challenging. Gynecologists often experience a similar dilemma. Despite advances, there is a considerable lack of consensus on pathogenesis and treatment options for patients with dysmenorrhea, premenstrual syndrome, mastalgia, infertility, menopausal symptoms, etc. Alterations in prostaglandin levels, inflammatory mediators, and estrogen/progesterone ratio have been proposed to contribute to the pathogenesis of these disorders. Dysmenorrhea is characterized by the turmoil of pain and abdominal cramps, which some menstruating women undergo every month/menstrual cycle; it depict's a high prevalence of 40%, and over 10% report severe restriction of routine activity for one to three days per cycle [1, 2] . Increased concentration of prostaglandins in the menstrual fluid is observed, and approaches to address it have become the principal remedy for primary dysmenorrhea. Premenstrual syndrome (PMS) is associated with bodily, emotional, and behavioral symptoms, mood swings, breast pain, anxiety, depression, acne, fatigue, headache, irritable bowel syndrome, and weight gain. Around 85% of menstruating women are affected by this condition. PMS is characterized by a decline in prostaglandin E 1 levels and increased responsiveness to prolactin which triggers abnormal tissue responses to estrogen and progesterone [8] . Also, an abnormal response to hormonal changes during the menstrual cycle and declining serotonin levels have been implicated. Mastalgia or breast pain occurs in 60-70% of women, and in 10 to 20% of these cases, it leads to significant impairment in daily living [14] . Infertility is a global public health issue, affecting 15% of all couples of reproductive ages. A quarter of male cases result from decreased semen quality [17] . Globally, 70 million couples experience subfertility or infertility. Male patients with infertility often have suboptimal semen quality. It results from altered physiological (elevated levels of reactive oxygen species), environmental, and genetic factors. Oligoasthenoteratozoospermia (OAT) is a common cause of male infertility.