Accepted Manuscript Regular Article Impact of the Strategy Adopted for Drug Loading in Nonporous Silica Nano- particles on the Drug Release and Cytotoxic Activity Benedetta Riva, Michela Bellini, Eleonora Corvi, Paolo Verderio, Ewa Rozek, Barbara Colzani, Svetlana Avvakumova, Annalisa Radeghieri, Maria Antonietta Rizzuto, Carlo Morasso, Miriam Colombo, Davide Prosperi PII: S0021-9797(18)30188-7 DOI: https://doi.org/10.1016/j.jcis.2018.02.040 Reference: YJCIS 23312 To appear in: Journal of Colloid and Interface Science Received Date: 21 December 2017 Revised Date: 12 February 2018 Accepted Date: 13 February 2018 Please cite this article as: B. Riva, M. Bellini, E. Corvi, P. Verderio, E. Rozek, B. Colzani, S. Avvakumova, A. Radeghieri, M. Antonietta Rizzuto, C. Morasso, M. Colombo, D. Prosperi, Impact of the Strategy Adopted for Drug Loading in Nonporous Silica Nanoparticles on the Drug Release and Cytotoxic Activity, Journal of Colloid and Interface Science (2018), doi: https://doi.org/10.1016/j.jcis.2018.02.040 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.