Accepted Manuscript Title: Evaluation of process simulation as a decisional tool for biopharmaceutical contract development and manufacturing organizations Authors: Kristina Pleitt, Balaji Somasundaram, Bradley Johnson, Evan Shave, Linda H.L. Lua PII: S1369-703X(19)30179-2 DOI: https://doi.org/10.1016/j.bej.2019.107252 Article Number: 107252 Reference: BEJ 107252 To appear in: Biochemical Engineering Journal Received date: 28 February 2019 Revised date: 4 May 2019 Accepted date: 31 May 2019 Please cite this article as: Pleitt K, Somasundaram B, Johnson B, Shave E, Lua LHL, Evaluation of process simulation as a decisional tool for biopharmaceutical contract development and manufacturing organizations, Biochemical Engineering Journal (2019), https://doi.org/10.1016/j.bej.2019.107252 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.