Accepted Manuscript Design, synthesis, cholinesterase inhibition and molecular modelling study of novel tacrine hybrids with carbohydrate derivatives João Paulo Bizarro Lopes, Luana Silva, Gabriela da Costa Franarin, Marco Antonio Ceschi, Diogo Seibert Lüdtke, Rafael Ferreira Dantas, Cristiane Martins Cardoso de Salles, Floriano Paes Silva-Jr, Mario Roberto Senger, Isabella Alvim Guedes, Laurent Emmanuel Dardenne PII: S0968-0896(18)31281-1 DOI: https://doi.org/10.1016/j.bmc.2018.10.003 Reference: BMC 14562 To appear in: Bioorganic & Medicinal Chemistry Received Date: 13 July 2018 Revised Date: 5 October 2018 Accepted Date: 7 October 2018 Please cite this article as: Lopes, J.P.B., Silva, L., da Costa Franarin, G., Antonio Ceschi, M., Seibert Lüdtke, D., Ferreira Dantas, R., de Salles, C.M.C., Paes Silva-Jr, F., Roberto Senger, M., Alvim Guedes, I., Emmanuel Dardenne, L., Design, synthesis, cholinesterase inhibition and molecular modelling study of novel tacrine hybrids with carbohydrate derivatives, Bioorganic & Medicinal Chemistry (2018), doi: https://doi.org/10.1016/j.bmc. 2018.10.003 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.