Research Article Solubility Enhancement of a Poorly Water-Soluble Drug Using Hydrotropy and Mixed Hydrotropy-Based Solid Dispersion Techniques Hezha Abdullah Ali 1 and Hunar Kamal Omer 2 1 Department of Pharmaceutics, College of Pharmacy, University of Duhok, Dahuk, Iraq 2 Department of Pharmaceutics, College of Pharmacy, awler Medical University, Erbil, Iraq CorrespondenceshouldbeaddressedtoHezhaAbdullahAli;hezha.ali@uod.ac Received 23 August 2022; Revised 31 October 2022; Accepted 3 November 2022; Published 28 November 2022 AcademicEditor:BenedettoNatalini Copyright©2022HezhaAbdullahAliandHunarKamalOmer.TisisanopenaccessarticledistributedundertheCreative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Purpose. Te biopharmaceutics classifcation system places rosuvastatin calcium in class II has a low and fuctuating oral bioavailability.Teresearchfocusistomaximizerosuvastatincalciumsolubilityinwateranddissolutionratebyemployingand combining various hydrotropic agents to make a solid dispersion using solvent evaporation techniques. Methodology. Te experimental study was conducted at Duhok University, College of Pharmacy. Initially, assess rosuvastatin’s solubility in hy• drotropicagentsincludingurea,mannitol,citricacid,sodiumbenzoate,andsodiumsalicylateatconcentrationsof10,20,30,and 40%w/v.Ten,variousratiosof2and3hydrotropicagentswereemployedtoreducetheconcentrationofeachhydrotropicagent. Byusingasolventevaporationprocedure,soliddispersionsweremade.Tesoliddispersionpowdersunderwentevaluationfor theirpercentagedrugcontent,percentageyield,solubility,dissolutiontest,XRD,DSC,SEM,andFTIR.Forstatisticalanalysis, GraphPadInStatDemosoftwarewasusedtoconductatwo•wayanalysisofvariance(ANOVA). Results.Incomparisontothe puredrug,thesolubilityofhydrotropicsoliddispersionsandphysicalmixturesofrosuvastatinwithacombinationofhydrotropic agents(sodiumsalicylate,sodiumbenzoate,andurea)intheratioof13.33foreachincreasedinallformulationssignifcantly,and all manufactured formulations’ drug release ranged from 98.83 to 104.78%, indicating a noticeably higher dissolution rate. Conclusion.Teconceptofmixedhydrotropicsoliddispersionwasshowntobeanoriginal,risk•free,andcost•efectivemethod for enhancing the bioavailability of drugs that have a low degree of solubility in water. 1. Introduction In pharmaceutical formulations, poorly soluble medicines are a concern. Because many novel medicines found by combinatorialchemistryandhigh•throughputscreeningare poorly soluble, making them poor prospects for new medications, improving their solubility characteristics is akeyhurdlethatmustbeaddressed.Becausepoorlysoluble medicines have limited absorption and bioavailability, it is critical to enhance their solubility and/or dissolution rate. Tere have been several ways described for improving the solubility of poorly soluble medicines [1]. Poorly water• soluble medications have been made more soluble using a variety of techniques, such as the following: particle size reduction, nanonization, hydrotropy, pH adjustment, sonocrystallization, supercritical fuid process, solid dis• persion, polymorphic alteration, inclusion complexation, surfactants, and liquisolid methods are just a few examples [2]. Surfactants: the traditional way to cause a difcult substance to dissolve is to lower the interfacial tension between the surface of the solute and the surface of the solvent. Tis allows for better wetting and interaction be• tween the solute and the solvent. Using amphiphilic sur• factants improves the solubility of drugs by lowering the surfacetensionbetweenthedrugandthesolvent,improving wetting properties, and promoting micellar solubilization. Adjusting the pH is the easiest and most common way to Hindawi Advances in Pharmacological and Pharmaceutical Sciences Volume 2022, Article ID 7161660, 16 pages https://doi.org/10.1155/2022/7161660