Targeting the Motion of Shikimate Kinase: Development of Competitive Inhibitors that Stabilize an Inactive Open Conformation of the Enzyme Verónica Prado, a Emilio Lence, a María Maneiro, a Juan C. Vázquez-Ucha, b Alejandro Beceiro, b Paul Thompson, c Alastair R. Hawkins, c and Concepción González-Bello* a a Centro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CIQUS) and Departamento de Química Orgánica, Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain. b Servicio de Microbioloxía-INIBIC, Complexo Hospitalario Universitario A Coruña (CHUAC), 15006 A Coruña, Spain. c Institute of Cell and Molecular Biosciences, Medical School, University of Newcastle upon Tyne, Newcastle upon Tyne NE2 4HH, UK. CORRESPONDING AUTHOR ADDRESS. Dr. Concepción González-Bello, Centro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CIQUS), Universidade de Santiago de Compostela, calle Jenaro de la Fuente s/n, 15782 Santiago de Compostela, Spain. FAX: +34 881 815704; Phone: +34 881 815726.