Research Article Repeated Cycles of Binge-Like Ethanol Intake in Adolescent Female Rats Induce Motor Function Impairment and Oxidative Damage in Motor Cortex and Liver, but Not in Blood Luanna Melo Pereira Fernandes, 1 Klaylton Sousa Lopes, 1 Luana Nazaré Silva Santana, 1 Enéas Andrade Fontes-Júnior , 1 Carolina Heitmann Mares Azevedo Ribeiro, 2 Márcia Cristina Freitas Silva, 3 Ricardo Sousa de Oliveira Paraense, 4 Maria Elena Crespo-López, 4 Antônio Rafael Quadros Gomes, 5 Rafael Rodrigues Lima , 6 Marta Chagas Monteiro , 5 and Cristiane Socorro Ferraz Maia 1 1 Laboratory of Pharmacology of Inflammation and Behavior, Faculty of Pharmacy, Institute of Health Science, Federal University of Pará, Belém, PA, Brazil 2 Laboratory of Immunology, Pharmacy Faculty, Institute of Health Science, Federal University of Pará, Belém, PA, Brazil 3 Laboratory of Ecotoxicology, Nucleus of Tropical Medicine, Federal University of Pará, Belém, PA, Brazil 4 Laboratory of Molecular Pharmacology, Institute of Biological Sciences, Federal University of Pará, Belém PA, Brazil 5 Laboratory of Microbiology and Immunology of Teaching and Research, Pharmacy Faculty, Institute of Health Science, Federal University of Pará, Belém PA, Brazil 6 Laboratory of Functional and Structural Biology, Institute of Biological Sciences, Federal University of Pará, Belém, PA, Brazil Correspondence should be addressed to Cristiane Socorro Ferraz Maia; crismaia@ufpa.br Received 28 April 2018; Revised 25 July 2018; Accepted 7 August 2018; Published 19 September 2018 Academic Editor: Stefania Schiavone Copyright © 2018 Luanna Melo Pereira Fernandes et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Moderate ethanol consumption (MEC) is increasing among women. Alcohol exposure usually starts in adolescence and tends to continue until adulthood. We aimed to investigate MEC impacts during adolescence until young adulthood of female rats. Adolescent female Wistar rats received distilled water or ethanol (3 g/kg/day), in a 3 days on-4 days off paradigm (binge drinking) for 1 and 4 consecutive weeks. We evaluate liver and brain oxidative damage, peripheral oxidative parameters by SOD, catalase, thiol contents, and MDA, and behavioral motor function by open-field, pole, beam-walking, and rotarod tests. Our results revealed that repeated episodes of binge drinking during adolescence displayed lipid peroxidation in the liver and brain. Surprisingly, such oxidative damage was not detectable on blood. Besides, harmful histological effects were observed in the liver, associated to steatosis and loss of parenchymal architecture. In addition, ethanol intake elicited motor incoordination, bradykinesia, and reduced spontaneous exploratory behavior in female rats. 1. Introduction Ethanol is one of the oldest psychoactive substances and remains the most intoxicating drug widely used by individ- uals [1]. In addition to having a cultural background and being accepted in almost all organized societies [1, 2], its con- sumption is favored by its low cost, wide availability, and easy access [2, 3]. However, the abuse of ethanol intake is consid- ered a public health problem with repercussions on the social environment and it causes several clinical complications [4] Hindawi Oxidative Medicine and Cellular Longevity Volume 2018, Article ID 3467531, 14 pages https://doi.org/10.1155/2018/3467531