Cronicon OPEN ACCESS EC PHARMACOLOGY AND TOXICOLOGY EC PHARMACOLOGY AND TOXICOLOGY Research Article Introduction Traditional herbal medicine, commonly known as phytomedicine, have re-emerged as an integral part of primary health care system in most of the developing and industrialized countries due to its lesser or no side effects and less expense compared to synthetic drugs [1,2]. Herbal medicinal plants had been traditionally used for the treatment of diabetes [3], an endocrinological disorder that is rapidly reaching almost endemic proportions throughout the world. According to the World Health Organization, the world diabetic population increased from 108 million in 1980 to 422 million in 2014. Among adults over 18 years of age, the percent of diabetic persons rose from 4.7% in 1980 to 8.5% in 2014, and this percent has been rising more rapidly in the less rich countries [4]. Diabetes is characterized by high blood glucose levels, passing of glucose in urine and frequent urination, but the disease may quickly progress to more complicated disorders like diabetic retinopathy, neuropathy and nephropathy [5]. In Bangladesh, the prevalence of diabetes is gradually rising in both urban and rural areas. Because of lack to modern clinical facilities and doctors, many tribal and below poverty level income diabetic patients resort to medicinal plants administered by folk and tribal me- dicinal practitioners for treatment of diabetes. We had been surveying and screening medicinal plants used by folk and tribal medicinal practitioners against diabetes for a number of years through oral glucose tolerance tests in mice [6-8]. Oral Glucose Tolerance Test with Methanolic Extract of Homalomena aromatica (Araceae) Whole Plant Citation: Mohammed Rahmatullah., et al. “Oral Glucose Tolerance Test with Methanolic Extract of Homalomena aromatica (Araceae) Whole Plant”. EC Pharmacology and Toxicology 8.11 (2020): 26-30. Razia Razzaque Noora, Promita Deb, Rownak Jahan, Rahat Al Mahamud, Khoshnur Jannat and Mohammed Rahmatullah* Department of Biotechnology and Genetic Engineering, University of Development Alternative, Lalmatia, Dhaka, Bangladesh *Corresponding Author: Mohammed Rahmatullah, Professor and Dean, Faculty of Life Sciences, Department of Biotechnology and Ge- netic Engineering, University of Development Alternative, Lalmatia, Dhaka, Bangladesh. Received: September 14, 2020; Published: October 07, 2020 Abstract Homalomena aromatica (Araceae) is an aromatic medicinal herb found in tropical Asia. Since scientific studies are absent on the anti-hyperglycemic efficacy of this herb so far, the objective of the present study was carried out to evaluate the possible antihyper- glycemic potential of methanolic extract of whole plant, which is traditionally used by the Marma tribe of Chittagong Hill Tracts, Bangladesh to keep elevated blood glucose level under control. Oral glucose tolerance test (OGTT) was used for evaluation of anti- hyperglycemic activity of methanolic extract of whole plant of Homalomena aromatica (MEHA). The results showed blood glucose levels were significantly reduced in glucose-challenged mice at the two evaluated doses of 200 and 400 mg MEHA per kg body weight by 62.0 and 68.3%, respectively, compared to untreated mice (control). Glibenclamide (an antihyperglycemic drug used as standard), when given to mice at a dose of 10 mg per kg body weight, resulted in a decrease of blood glucose level by 61.0%, demonstrating that in this regard both doses of MEHA were better than glibenclamide. The results suggest that the Marmas are valid in using the whole plant to decrease glucose levels in blood. Keywords: Homalomena aromatica; Antihyperglycemic Efficacy; OGTT; Type 2 Diabetes Mellitus