Majalah Kedokteran Gigi Indonesia Vol 7 No 2 – August 2021 ISSN 2460-0164 (print), ISSN 2442-2576 (online) Available online at https://jurnal.ugm.ac.id/mkgi DOI: http://doi.org/10.22146/majkedgiind.53419 110 RESEARCH ARTICLE Efect of advanced-platelet rich-fbrin combined with rosuvastatin application after open fap debridement of infrabony pocket Tissa Rahadianti*, Dahlia Herawati**, Kwartarini Murdiastuti** *Periodontics Specialty Program, Faculty of Dentistry, Universitas Gadjah Mada, Yogyakarta, Indonesia **Department of Periodontics, Faculty of Dentistry, Universitas Gadjah Mada, Yogyakarta, Indonesia **Jl Denta No 1 Sekip Utara, Yogyakarta, Indonesia;  correspondence: kmurdiastuti@ugm.ac.id ABSTRACT Open fap debridement (OFD) is an invasive therapy for chronic periodontitis with pocket 5 mm or more. However, it is difcult to achieve regeneration and new attachment with this therapy. Periodontitis starts to add growth factors and local drugs delivery as host modulation therapy. Advanced-PRF (A-PRF) contains more growth factor than PRF which plays a role in promoting fbroblast proliferation, reepithelization, extracellular matrix production, and endothelial cell migration. 1.2% rosuvastatin gel (RSV) is a local delivery drug with a pleiotropic efect that can modify host response to promoting BMSCs, BMP-2, OPG, ALP, RANKL, and osteoblasts. This study aimed to examine the efect of the application of A-PRF+RSV in OFD therapy of which the parameters were probing depth (PD), relative attachment loss (RAL), and alveolar bone height. The study samples consisted of 24 periodontal pockets which were divided into 2 groups of 12 pockets each, namely A-PRF+RSV for group 1 and PRF+RSV for group 2. Clinical evaluations were carried out on baseline, day-30, and day-90 for PD and RAL, and on baseline and day -90 for alveolar bone height. Data of PD and RAL reduction were analyzed with non-parametric test Mann-Withney, while data of reduction of alveolar bone height were analyzed with parametric Independent-T test. Group 1 obtained a statistically more signifcant result in reducing PD, RAL, and alveolar bone height compared to group 2 (p<0.05) To conclude, the application of A-PRF and 1.2% rosuvastatin gel in OFD procedure promotes a higher PD and RAL reduction and alveolar bone height increase than the application of PRF coupled with 1.2% rosuvastatin gel. Keywords: advanced platelet rich-fbrin; chronic periodontitis; open fap debridement; periodontal pocket; rosuvastatin INTRODUCTION Periodontitis is the second most common dental and oral diseases in Indonesia with a prevalence of 60% of Indonesia’s population. 1 The main etiology of periodontitis is plaque and calculus bacteria that infect the supporting tissues of the teeth like gingiva, periodontal ligament, cementum, and alveolar bone. 2 Based on the severity, periodontitis is divided into 3 phases: mild, moderate, and severe. These three phases are determined based on clinical examinations of probing depth, bleeding on probing, clinical attachment loss, and radiographic bone loss. 3 Treatment of periodontal disease based on severity are scaling root planning (SRP), curettage, or open fap debridement (OFD). 4 Treatment of periodontitis has now shifted from simply eliminating the etiological factors and controlling the predisposing factors to obtaining new periodontal attachment. 4,5,6 The principle of a periodontal tissue regeneration treatment is a continuous complex process of cell adhesion, migration, proliferation, and diferentiation. 7 Open fap debridement only eliminates the etiologic factors but could not restore the structure of periodontal tissues which are damaged and lost due to bacterial infections, 6,8 so research on a variety of growth factors and host modulation drugs has started to be conducted in OFD treatment to enhance tissue regeneration and periodontal treatment success. 5,9 Previous research by Suwondo et al (2018) showed that Advanced-Platelet Rich Fibrin (A-PRF) was able to regenerate the periodontal tissues better than the conventional Platelet Rich Fibrin (PRF) based on parameters of probing depth (PD) and relative attachment loss. However, there was no diference in the increase in alveolar bone height because PRF only had an efect on the frst initial stage, i.e., osteogenesis phase by optimizing osteoblast diferentiation. 10