* Corresponding author: American Institute for Goat Research at Langston University, Langston, OK 73034, US. E- mail address: yonathan.tilahun@langston.edu (Y. Tilahun) Short communication Quantitative and Qualitative Improvements in DNA Extraction Procedures Using a Bronopol TM Tablet in Alpine Goat Milk Ashley Newton, Amber L. Martin, Yonathan Tilahun*, and Steve Zeng. American Institute for Goat Research at Langston University, Langston, OK 73034, US. 1. Introduction Alpine goat milk contains a community of somatic cells associated with the mammary glands of the milk goat. The somatic cells are important indicators for things such as identifyng the presence of mastitis in the goat or for DNA extraction of cells directly associated with goat milk. A study has not been completed where the quantitative and qualitative DNA extraction results ARTICLE INFO Keywords: Goat milk Somatic cells Bronopol ABSTRACT Preservation of milk is important as it relates to Capra aegagrus hircus (Alpine goat) milk DNA extraction. We examined the difference in concentration and quality of DNA resulting from the use of a preservation tablet (Bronopol TM ) versus a preservation solution by Norgen Biotek. When examining the concentration and quality of DNA in goat milk for studies using somatic cells from goat milk, it is ideal to use a substance that has a long-term preservation potential. The concentrations and quality of DNA obtained from goat milk was compared. Two separate trial samples of Alpine goat milk were obtained. The preservation tablet commonly known as B-14 or Bronopol TM was dissolved into one sample of milk. Another sample of goat milk without a tablet used a preservation solution from a Norgen Biotek. All DNA extraction methods followed the Norgen Biotek Corp. manufacturer’s protocol. DNA quantity and quality was analyzed using a Thermo Scientific NanodropLite spectrophotometer. The study showed that the traditional Bronopol TM was a better method of preserving and maintaining the integrity of DNA in the somatic cells that are present in Alpine goat milk. This is based on the results obtained following determination of quantity and A260/A280 readings for quality assessment. Thus, the use of Bronopol TM is the preferred method of preserving goat milk for DNA extraction.