ARTICLE IN PRESS G Model Arch Bronconeumol. 2018;xxx(xx):xxx–xxx www.archbronconeumol.org Original Article Lung Retransplantation Due to Chronic Lung Allograph Dysfunction: Results From a Spanish Transplant Unit  Eva Revilla-López, a Cristina Berastegui, a,∗ Berta Sáez-Giménez, a Manuel Lopez-Meseguer, a Victor Monforte, a,b Carlos Bravo, a,b Judith Sacanell Lacasa, c Laura Romero Vielva, d Antonio Moreno Galdo, e Antonio Roman a,b a Servicio de Neumologia, Hospital Vall d’Hebron Barcelona, Universitat Autònoma de Barcelona, Barcelona, Spain b Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Madrid, Spain c Servicio de Cuidados Intensivos, Hospital Vall d’Hebron Barcelona, Universitat Autònoma de Barcelona, Barcelona, Spain d Servicio de Cirugia Torácica, Hospital Vall d’Hebron Barcelona, Universitat Autònoma de Barcelona, Barcelona, Spain e Servicio de Pediatria, Hospital Vall d’Hebron Barcelona, Universitat Autònoma de Barcelona, Barcelona, Spain a r t i c l e i n f o Article history: Received 21 May 2018 Accepted 25 July 2018 Available online xxx Keywords: Chronic lung allograft dysfunction Lung retransplantation Lung transplantation a b s t r a c t Introduction: Long-term survival of lung transplantation (LT) patients is mainly limited by the devel- opment of chronic lung allograft dysfunction (CLAD). Lung retransplantation (LR) is an alternative for a selected population. The aim of this study was to review the LR experience in our center. Patients and methods: We conducted a retrospective study of patients undergoing LR between August 1990 and July 2017. Results: Fourteen LR out of a total of 998 (1.4%) LT were performed. Twelve patients (85.7%) underwent LR due to CLAD: 10 (71.4%) because of bronchiolitis obliterans syndrome and 2 (14.3%) due to restrictive allograft syndrome. LR was performed in 2 patients within 30 days of the first LT. In those who under- went LR due to CLAD, mean time between the first LT and LR was 48 months, and mean duration of invasive mechanical ventilation was 32 days. The increase in FEV 1 after LR was 24±18%. The best spirom- etry values were observed after 7.3 months. Mean survival of the cohort was 43.8 months. In patients with bronchiolitis obliterans syndrome, mean survival was 63.4 months, while in those with restrictive allograft syndrome, it was 19.5 months. Only 1 of the 2 early LR patients survived. Conclusion: LR is a therapeutic option in selected patients with CLAD, with acceptable survival. Indication for LR early after LT shows poor outcomes. © 2018 SEPAR. Published by Elsevier Espa ˜ na, S.L.U. All rights reserved. Resultados del retrasplante pulmonar por disfunción crónica del injerto pulmonar en un centro trasplantador: Hospital Vall D’Hebron de Barcelona Palabras clave: Disfunción crónica del injerto Retrasplante pulmonar Trasplante pulmonar r e s u m e n Introducción: La supervivencia del trasplante pulmonar (TP) viene condicionada fundamentalmente por el desarrollo de disfunción crónica del injerto (DCI). El retrasplante pulmonar (RP) es una alternativa para una población seleccionada con DCI. El objetivo del estudio fue revisar la experiencia de RP en nuestro centro. Pacientes y métodos: Se ha realizado un estudio retrospectivo de los pacientes sometidos a RP entre agosto de 1990 y julio de 2017.  Please cite this article as: Revilla-López E, Berastegui C, Sáez-Giménez B, Lopez-Meseguer M, Monforte V, Bravo C, et al. Resultados del retrasplante pulmonar por disfunción crónica del injerto pulmonar en un centro trasplantador: Hospital Vall D’Hebron de Barcelona. Arch Bronconeumol. 2018. https://doi.org/10.1016/j.arbres.2018.07.025 ∗ Corresponding author. E-mail address: cberaste@vhebron.net (C. Berastegui). 1579-2129/© 2018 SEPAR. Published by Elsevier Espa ˜ na, S.L.U. All rights reserved. ARBR-1980; No. of Pages 5