European Journal of Molecular & Clinical Medicine ISSN 2515-8260 Volume 07, Issue 11, 2020 6509 Oro Facial Orofacial Space Infections in Medically Compromised Patients- A Systematic Review & Meta Analysis Dr. Akshay Mishra 1 , Dr. Vikram V Khare 2 , Dr. Mohammed Muzammil Khan 3 , Dr. Puneeta Vohra 4 , Dr. Jayendra Purohit 5 , Dr. Anil Budumuru 6 1. Associate Professor, Department of Oral and Maxillofacial Surgery, Swargiya Dadasaheb Kalmegh Smruti Dental College and Hospital, Wanadongri- Wadhamna Road, Hingna, Dist - Nagpur 441110, Maharashtra (Corresponding author); 2. Professor and Head, Oral Medicine and Radiology, Dr.DY Patil Vidyapeeth Pune, Maharashtra; 3. Specialist Pedodontist, Ministry of health, Taif, Kingdom of Saudi Arabia; 4. Associate Professor , Dept Of Oral Medicine And Radiology, Faculty Of Dental Sciences , SGT University, Gurgaon, Haryana, India; 5. Professor, Department of Oral and Maxillofacial Surgery College of Dental Sciences and Hospital, Sihor, Amargadh, Bhavnagar, Gujarat; 6. MDS, Senior lecturer, Department of Oral and Maxillofacial surgery, Vishnu Dental college, Bhimavaram, Andhra Pradesh. 1 Email: akshaym21@gmail.com Abstract: Introduction: This study reviews our understanding with Orofacial space infections requiring surgical intervention, including cervical necrotizing fasciitis in medically compromised patients. The purpose of the study was to recognize predisposing and aggravating factors of the disease and identify the possible factors that can lead to life-threatening complications and slow down the healing process Materials and methods: We associate the results to previous data from 1985 to 2005 to discover possible changes and varying trends. The features of four lethal cases are defined. This retrospective analysis comprises patient data from 2005 to 2015 in tertiary referral hospital and in total, 277 patients were seen. Results: Surgical drainage through a neck opening with/without intraoral incision was made in 215 (77.6%) patients; an intraoral incision was only done in 62 patients (22.4%). ICU care was needed in 66 (23.8%). Odontogenic etiology (44.8%) was the most usual origin. The most common comorbidity was a psychiatric disorder and/or dementia and occurred in 55 (19.9%)