Differences in Early Acetaminophen Hepatotoxicity Between Obese ob/ob and db/db Mice Jacinthe Aubert, Karima Begriche, Matthieu Delannoy, Isabelle Morel, Julie Pajaud, Catherine Ribault, Sylvie Lepage, Mitchell R. McGill, Catherine Lucas-Clerc, Bruno Turlin, Marie-Anne Robin, Hartmut Jaeschke, and Bernard Fromenty INSERM, U991 (J.A., K.B., M.D., I.M., J.P., C.R., M.-A.R., B.F.) and Plate-forme d’Histopathologie H2P2, Biosit (B.T.), Université de Rennes 1; Laboratoire de Toxicologie Biologique et Médico-légale (I.M., S.L.), Laboratoire de Biochimie Générale, (C.L.-C.), and Département d'Anatomie et Cytologie Pathologiques (B.T.), Hôpital Pontchaillou Rennes, France; Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center (M.R.M., H.J.), Kansas City, KS, USA JPET Fast Forward. Published on May 30, 2012 as DOI:10.1124/jpet.112.193813 Copyright 2012 by the American Society for Pharmacology and Experimental Therapeutics. This article has not been copyedited and formatted. The final version may differ from this version. JPET Fast Forward. Published on May 30, 2012 as DOI: 10.1124/jpet.112.193813 at ASPET Journals on December 12, 2021 jpet.aspetjournals.org Downloaded from