Research Article Implication of High Body Fat Percentage on Migraine Chronification in Premenopausal Females Pooja Ojha 1 and Varun Malhotra 2 1 All India Institute of Medical Sciences, Jodhpur, Rajasthan, India 2 Era’s Lucknow Medical College, Lucknow, Uttar Pradesh, India Correspondence should be addressed to Pooja Ojha; drpojha@gmail.com Received 18 May 2022; Revised 10 August 2022; Accepted 29 September 2022; Published 15 October 2022 Academic Editor: Pragney Deme Copyright © 2022 Pooja Ojha and Varun Malhotra. is is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Background. Chronic migraine, being a debilitating headache disorder, needs assessment of the risk factors implicated in its occurrence. We investigated the potential role of obesity as a risk for chronic migraine in premenopausal females with episodic migraine. Methods. In this analytical study, body fat% was compared between episodic and chronic migraine patient groups. e standard criteria of the international classification of headache disorder were used for the diagnosis. Demographic data, clinical details of migraine, and anthropometric measurements were collected using structured questions and standardized techniques. Pearson’s correlation (r) was estimated to assess the concordance between body fat% and migraine frequency. High body fat%’s implication on chronic migraine which was adjusted for body mass index (BMI), and the use of oral contraceptives was determined using logistic regression analysis. Results. A total of 168 premenopausal female migraineurs, with a mean (Standard deviation) age of 33.0 (±9.0) years, were enrolled in the study. BMI and high body fat% were significantly associated with chronic migraine (p < 0.05). ere was a weak positive, but significant, correlation between body fat% and migraine frequency (r = 0.185, p < 0.017). e presence of high body fat was found to increase the risk of chronic migraine by 2.8 times (confidence interval 1.4–5.6; p < 0.003). Conclusion. e amount of fat mass in the body relates to the clinical characteristics of migraine. ere is an increased risk of developing chronic migraine in patients having high body fat. Weight control measures can be targeted for the prevention of migraine worsening. 1. Introduction Migraine symptomatology and disability are heterogeneous in presentation and vary in combinations [1]. Migraine headache has been found to be influenced by a myriad of predisposing factors, wherein some of them may probably play a role as migraine precipitants [2]. An unattended moderate intensity headache can gradually worsen over time and accentuate in frequency. Reportedly, about 3% of pa- tients with episodic migraine, attack frequency less than 15 per month, can eventually transform into chronic disease in due course of months to years [3]. Reported literature suggests the role of obesity as a risk towards migraine chronification and the need of additional attention towards the treatment of obese patients [4]. Notably, body fat plays a significant role in physiological and pathological mechanisms as it can affect the action of various drugs, enzymes, and chemicals. Association of body mass index (BMI), a prevalent method for estimating obesity, with migraine has been studied in previous research [5, 6]. BMI has been found to have limited potential when used alone as it does not take into account age, gender, and ethnicity, nor does it differentiate between total body fat mass and lean mass [7]. In addition, BMI has been reported to be an inconsistent predictor of morbidity and mortality in a systematic review [8]. Comparatively, body fat percentage (BF%) is an estimate of the percentage of fat in the body composition [9]. BF% has been found to play a significant role in distinguishing the obese individuals from the healthy ones owing to the greater ability to detect lean mass and fat Hindawi Neurology Research International Volume 2022, Article ID 8219254, 5 pages https://doi.org/10.1155/2022/8219254