E-Mail karger@karger.com Mini Review Horm Res Paediatr 2013;79:257–270 DOI: 10.1159/000351025 Personalized Approach to Growth Hormone Treatment: Clinical Use of Growth Prediction Models J.M. Wit a M.B. Ranke b K. Albertsson-Wikland c A. Carrascosa d R.G. Rosenfeld e S. Van Buuren f, g B. Kristrom h E. Schoenau i L. Audi d A.C.S. Hokken-Koelega j P. Bang k H. Jung l W.F. Blum l L.A. Silverman m P. Cohen n S. Cianfarani o, p C. Deal q P.E. Clayton r L. de Graaff j, s J. Dahlgren c J. Kleintjens t M. Roelants u a Department of Pediatrics, Leiden University Medical Center, Leiden, The Netherlands; b Paediatric Endocrinology Section, Children’s Hospital, University of Tübingen, Tübingen, Germany; c Göteborg Pediatric Growth Research Center (GP-GRC), Department of Pediatrics, Institute of Clinical Science, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; d Departments of Paediatrics and Paediatric Endocrinology Research Unit, Vall d’Hebron Institut de Recerca (VHIR), Hospital Vall d’Hebron, Autonomous University of Barcelona, CIBERER (Centre for Biomedical Research on Rare Diseases), Instituto de Salud Carlos III, Barcelona, Spain; e Department of Pediatrics, Oregon Health and Science University, Portland, Oreg., USA; f TNO Quality of Life, Leiden, and g Department of Biostatistics, Utrecht University, Utrecht, The Netherlands; h Department of Pediatrics, Institute of Clinical Science, Umeå University, Umeå, Sweden; i Department of Pediatrics, University of Cologne, Cologne, Germany; j Department of Pediatric Endocrinology, Erasmus Medical Center, Rotterdam, The Netherlands; k Division of Pediatrics, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linköping University, Linköping, Sweden; l Lilly Research Laboratories, Bad Homburg, Germany; m Goryeb Children’s Hospital, Atlantic Health System, Morristown, N.J., n Ethel Percy Andrus Gerontology Center, USC Davis School of Gerontology, University of Southern California, Los Angeles, Calif., USA; o Molecular Endocrinology Unit, ‘Bambino Gesù’ Children’s Hospital, Rome, Italy; p Department of Women’s and Children’s Health, Karolinska Institutet, Stockholm, Sweden; q Endocrine Service, Hôpital Sainte-Justine, Université de Montréal, Montréal, Qué., Canada; r Paediatric Endocrinology, Royal Manchester Children’s Hospital, and Manchester Academic Health Sciences Centre, University of Manchester, Manchester, UK; s Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands; t Quintiles Consulting, Hawthorne, N.Y., USA; u Department of Anthropogenetics, Vrije Universiteit Brussel, Brussels, Belgium Abstract The goal of growth hormone (GH) treatment in a short child is to attain a fast catch-up growth toward the target height (TH) standard deviation score (SDS), followed by a mainte- nance phase, a proper pubertal height gain, and an adult height close to TH. The short-term response variable of GH treatment, first-year height velocity (HV) (cm/year or change Key Words Growth hormone deficiency · Idiopathic short stature · Small for gestational age · Insulin-like growth factor I · Growth hormone receptor Received: December 20, 2012 Accepted: April 2, 2013 Published online: May 28, 2013 HORMONE RESEARCH IN PÆDIATRICS Dr. J.M. Wit Department of Pediatrics Leiden University Medical Center NL–2300 Leiden (The Netherlands) E-Mail J.M.Wit  @  lumc.nl © 2013 S. Karger AG, Basel 1663–2818/13/0795–0257$38.00/0 www.karger.com/hrp