Age-Related Changes of Elements in the Anterior Commissures and the Relationships Among their Elements Nutcharin Ongkana & Setsuko Tohno & Yoshiyuki Tohno & Patipath Suwannahoy & Pasuk Mahakkanukrauh & Cho Azuma & Takeshi Minami Received: 8 June 2009 / Accepted: 3 August 2009 / Published online: 25 August 2009 # Humana Press Inc. 2009 Abstract To elucidate compositional changes of the anterior commissure with aging, the authors investigated age-related changes of elements in the anterior commissures and the relationships among their elements. After ordinary dissection at Nara Medical University was finished, the anterior commissures were resected from 45 subjects, ranging in age from 70 to 101 years. The subjects consisted of 22 men and 23 women. After ashing with nitric acid and perchloric acid, the element content of the anterior commissures was determined by inductively coupled plasma-atomic emission spectrometry. The seven element contents of Ca, P, S, Mg, Zn, Fe, and Na did not change significantly in the anterior commissures with aging. Regarding the relationships among their element contents, significant correlations were found among the contents of Ca, Mg, Zn, and Na in the anterior commissures. The gender difference that the Zn content was significantly higher in men than in women was found in the anterior commissure. Keywords Anterior commissure . Element . Calcium . Phosphorus . Zinc . Aging Introduction To elucidate compositional changes of the tissues with aging, the authors investigated age- related changes of elements in various tissues. Age-related changes of elements in the Biol Trace Elem Res (2010) 135:86–97 DOI 10.1007/s12011-009-8496-5 N. Ongkana : S. Tohno : Y. Tohno (*) : P. Suwannahoy : P. Mahakkanukrauh Department of Anatomy, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand e-mail: ytohno@med.cmu.ac.th S. Tohno : Y. Tohno : C. Azuma Department of Anatomy, Nara Medical University School of Medicine, Kashihara, Nara 634-8521, Japan T. Minami Laboratory of Environmental Biology, Department of Life Science, Faculty of Science and Engineering, Kinki University, Higashi-Osaka, Osaka 577-8502, Japan