Abstract Background: In recent decades, the use of information and communication technologies (ICT) for educational purposes has increased, and the spread of network technologies has caused e-learning practices to evolve signifcantly. E-learning is used increasingly in healthcare professionals' education. In higher education, audio and video productions prove efective in enhancing student-learning outcomes and increase student satisfaction. Aim of the study: Te purpose of the study is to investigate the efectiveness of e-learning in enhancing neonatal resuscitation skills, knowledge and confdence of undergraduate nursing students. Material and methods: Forty undergraduate students who registered for Pediatric course from College of Nursing-Jeddah were recruited for the study. A single-blind Randomized Control Trial design was used. Nursing students of the control group allocated to the tradition method of demonstration and re-demonstration of neonatal resuscitation skills in nursing lab while the nursing students of the experimental have access to video about neonatal resuscitation in addition to the tradition method. Results: Te results of the current study revealed that the nursing students of the experimental group were more skillful and had more knowledge about neonatal resuscitation than the nursing students of the control group and the diferences were not statistically signifcant. Moreover, it was found that the nursing students of the control group reported higher level of self-confdence than nursing students of the experimental group and the diference was not statistically signifcant. Conclusion and recommendation: Te results of current study revealed improvement in nursing students’ skills, knowledge about neonatal resuscitation but the diferences was not statistically signifcant. Further researches are necessary with increasing the number of students and video-viewing frequency may afect the learning outcomes. The Effectiveness of E-Learning in Enhancing Neonatal Resuscitation Skills, Knowledge and Confidence of Undergraduate Nursing Students Publication History: Received: October 07, 2014 Accepted: November 10, 2014 Published: November 12, 2014 Keywords: Student nurses, E-learning, Neonatal resuscitation, Skills, Knowledge, Self confdence Research Article Open Access Background In recent decades, the use of information and communication technologies (ICT) for educational purposes has increased, and the spread of network technologies has caused e-learning practices to evolve signifcantly [1,2]. E-learning or online learning is used increasingly in healthcare professionals’ education. Tere is no single agreed defnition of e-learning, but it generally refers to internet based forms of learning, rather than face to face interaction and where traditional methods of learning are supported by online resources [3]. Sangra et al. [4] did a study to create an inclusive defnition of e-learning that would be accepted by the majority of the scientifc community and would also defne the boundaries for future activity in this sector. In this context and afer taking into consideration all experts’ comments and arguments, a preliminary defnition of e-learning was prepared. Te preliminary defnition was as follows: “E-learning is an approach to teaching and learning, representing all or part of the educational model applied, that is based on the use of electronic media and devices as tools for improving access to training, communication and interaction and that facilitates the adoption of new ways of understanding and developing learning”. In higher education, audio and video productions prove efective in enhancing student-learning outcomes and increase student satisfaction. Moreover, Apple Computer’s iPod and iPad are becoming a part of healthcare professional education and patient-centered care. Educause Center for Applied Research (ECAR) studies (2005) revealed that the vast majority of the student respondents own at least one computer and a cell phone. Tese technologies are used on a daily basis for studying, social interaction, and entertainment. Students * Corresponding Author: Dr. Wafaa Elarousy, College of Nursing - Jeddah, King Saud Bin Abdulaziz University for Health Science, Saudi Arabia; E-mail: arousywa@ngha.med.sa Citation: Elarousy W, Abdulshakoor E, Bafail R, Shebaili M (2014) The Effectiveness of E-Learning in Enhancing Neonatal Resuscitation Skills, Knowledge and Confdence of Undergraduate Nursing Students. Int J Nurs Clin Pract 1: 102. doi: http://dx.doi.org/10.15344/2394-4978/2014/102 Copyright: © 2014 Elarousy et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. International Journal of Nursing & Clinical Practices Wafaa Elarousy 1,2* , Ebtesam Abdulshakoor 1 , Ranya Bafail 1 and Makiah Shebaili 1 1 College of Nursing - Jeddah, King Saud Bin Abdulaziz University for Health Science, Saudi Arabia 2 Faculty of Nursing, Alexandria University, Egypt Int J Nurs Clin Pract IJNCP, an open access journal ISSN: 2394-4978 Volume 1. 2014. 102 Elarousy W et al., Int J Nurs Clin Pract 2014, 1: 102 http://dx.doi.org/10.15344/2394-4978/2014/102 are increasingly using a combination of cell phones, laptops and personal digital assistant (PDAs) and about 25% have wireless adaptors. Virtually all have access to the internet and the majority has broadband access. Furthermore, it was found that 64.1% of the students perceive that IT used in courses improves learning [5]. Virtual reality application is one of the interactive e-learning approaches which provide efective stimulating situations [6]. Researchers integrate it to other simulations and e-learning strategies on order to provide safe environments. Immersive of high- fdelity standardized virtual simulation allow the evaluators to evaluate the critical thinking, decision making in emergency situation, and skill performance which could enhance the nursing student abilities[7]. Tere are many advantages of e-learning. For learners, learning is self-paced and gives student a chance to speed up or slow down as necessary, convenient for students to access any time, any place ,self directed allowing the students to choose content and tool. For