Bagwan et al., IJPSR, 2023; Vol. 14(1): 434-443. E-ISSN: 0975-8232; P-ISSN: 2320-5148 International Journal of Pharmaceutical Sciences and Research 434 IJPSR (2023), Volume 14, Issue 1 (Research Article) Received on 14 May 2022; received in revised form, 28 June 2022; accepted, 29 July 2022; published 01 January 2023 A SIMPLE, EFFICIENT AND GREEN PROCEDURE FOR THE SYNTHESIS OF 2, 4, 5- TRISUBSTITUTED IMIDAZOLE DERIVATIVES USING NOVEL PEG-SOCl AS A CATALYST Shahabaj M. Bagwan * 1 , Saifuddin Quazi 1 , Mazahar Farooqui 1 and Mohamad Asif 2 Maulana Azad Research Center 1 , Department of Chemistry 2 , Maulana Azad College, Aurangabad - 431001, Maharashtra, India. ABSTRACT: A facile, highly efficient, simple, and convenient method for synthesizing 2, 4, 5-trisubstituted imidazole derivatives from the condensation of various substituted benzaldehyde, benzil, and ammonium acetate by using a catalytic amount of PEG-SOCl in the presence of water at room temperature or under microwave irradiation. PEG-SOCl is an effective heterogeneous catalyst and easy to separate. We have investigated that PEG-SOCl catalytic system was excellent recycled and reused three times without any loss of catalytic activity. PEG-SOCl act as a green catalyst, low-cost, non-volatile, non-hazardous, environmental friendly catalyst, and water is a green solvent reaction carried out at room temperature or under microwave radiation method shows greater advantages because it has contributed in the green chemistry aspects. The prepared catalyst was analyzed by analytical methods such as infrared spectrum (IR), X-Ray diffraction pattern (XRD), thermo-gravimetric analysis (TGA), and BET surface analysis. Spectroscopic techniques identified the synthesized pure product (1j), including infra-red (IR) spectrum, 1 H and 13 C NMR spectrum and Mass (LC-MS) spectrometry. INTRODUCTION: Imidazole derivatives are important and famous heterocyclic compound which shows the general and key structure of features of a variety of medicinal Pharmaceutical and natural products. Essential and synthetic imidazole derivatives occupy the main place among pharmaceutically and medicinally important compounds due to their different interesting and widespread medicinal Pharmaceutical and biological activity such as anti-oxidant 1-2 , anti- viral 3-4 , anti-cancer 5-6 , anti-inflammatory 7-8 , anti- tuberculosis 9-10 , anti-bacterial 11-12 , antifungal 13-14 , anti-diabetic 15-16 , anti-microbial 17-18 , anti- convulsant 19 , cytotoxic 20-21 , antiproliferative 22 , anticandidal 23 , antiamoebic 24 activity, etc. QUICK RESPONSE CODE DOI: 10.13040/IJPSR.0975-8232.14(1).434-43 This article can be accessed online on www.ijpsr.com DOI link: http://dx.doi.org/10.13040/IJPSR.0975-8232.14(1).434-43 Imidazole and its derivatives involve one pot and the multicomponent reaction of substituted benzaldehyde, benzil, and ammonium acetate by using a PEG-SOCl as a green catalyst in aqueous media at room temperature or under microwave irradiation. The various synthetic methods have been developed for the synthesis of imidazole derivatives in the presence of different catalysts such as poly (4-vinylpyridine) supported TiCl 4 or [P 4 -VP]-Ti(IV) 25 , Amberlite IR 120H+ 26 , Appel reagent (Ph 3 P/CCl 4 ) 27 , Sulfonic Acid Magnetic Graphene Oxide (Fe3O4@GO-Pr-SO 3 H) 28 , Fly Ash Supported Bi 2 O 3 –ZnO 29 , Pyrrolidinium Hydrogen Sulfate (PHS) as the ionic liquid catalyst 30 , Pd/AlO(OH) NPs 31 , Urea/Hydrogen Peroxide (UHP) 32 , Nano-Zirconia (nano ZrO 2 ) 33 , Silver nanoparticles 34 , Copper Oxide nanoparticles 35 etc. Green chemistry aims for alternative, environmentally friendly reaction media to increase reaction rates and lower reaction temperatures. Green chemistry principle that the method in chemical sciences that readily uses renewable raw Keywords: Multicomponent reaction, PEG-SOCl, Microwave, Green solvent, Imidazole derivatives Correspondence to Author: Shahabaj M. Bagwan Maulana Azad Research Center, Maulana Azad College, Aurangabad - 431001, Maharashtra, India. E-mail: bagwanshahabaj@gmail.com