Research Article Trend of Bacterial Uropathogens and Their Susceptibility Pattern: Study of Single Academic High-Volume Center in Italy (2015–2019) Enrica Serretiello, 1 Veronica Folliero , 2 Biagio Santella, 1 Giuseppina Giordano, 1 E. Santoro, 3 Francesco De Caro, 4 Pasquale Pagliano, 3 Matteo Ferro, 5 Silvana M. Aliberti, 4 Mario Capunzo, 4 Massimiliano Galdiero, 2 Gianluigi Franci , 4 and Giovanni Boccia 4 1 Section of Microbiology and Virology, University Hospital “Luigi Vanvitelli”, Naples 80138, Italy 2 Department of Experimental Medicine, University of Campania “Luigi Vanvitelli”, Naples 80138, Italy 3 Department of Sanitary Hygiene and Evaluative Medicine U.O.C. Clinical and Microbiological Pathology, S. Giovanni di Dio and Ruggi D’Aragona University Hospital, “Scuola Medica Salernitana”, Largo Citt` a di Ippocrate, Salerno 84131, Italy 4 DepartmentofMedicine,SurgeryandDentistry“ScuolaMedicaSalernitana”,UniversityofSalerno,Baronissi84081,SA,Italy 5 Division of Urology, European Institute of Oncology, IRCCS, Milan, Italy CorrespondenceshouldbeaddressedtoGianluigiFranci;gfranci@unisa.it Received 22 February 2021; Accepted 6 April 2021; Published 21 April 2021 AcademicEditor:JosephFalkinham Copyright©2021EnricaSerretielloetal.isisanopenaccessarticledistributedundertheCreativeCommonsAttribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Urinary tract infections (UTIs) are a very widespread infection that can occur in disparate age range, in both sexes and in pregnancy/menopause state. Treatment of UTIs is difficult due to the emergence of antibiotic-resistant bacterial strains. e present study shows five years of data collected on patients admitted at the University Hospital “San Giovann di Dio e Ruggi d’Aragona”inSalerno,Italy.einvestigationexhibitstheincidenceoftheinfection,ofthegender,andoftheagegroupaffected, identifyingthemostrepresentativebacteriainvolved,drawingtheirprofileofantimicrobialresistance.Bacterialidentificationand antibioticsusceptibilitytestingwereperformedusingtheVITEK2system.Amongthe46382studiedpatients,9896(21.34%)and 36486 (78.66%) were positive and negative for microorganism growth, respectively. Of 9896 positive patients, 6158 (62.23%) femalesand3738(37.77%)maleswereidentified.ehighestincidenceofpositivesubjects(56.66%)wasrecordedintheelderly (>61years).8431(85.20%)uropathogenswereGram-negative,1367(13.81%)wereGram-positive,and98(0.99%)were Candida species(Candida spp.). Escherichia coli (E. coli) and Enterococcus faecalis (E. faecalis) werethemostrepresentativeGram-negative andGram-positivestrains,respectively.eGram-negativebacteriamostrepresentativewerehighlyresistanttoampicillin,whereas among the Gram-positive bacteria, E. faecalis was highly resistant to gentamicin and streptomycin high level synergy, and En- terococcus faecium (E. faecium) to ampicillin, ampicillin/sulbactam, and imipenem. is retrospective work investigates the local epidemiologicaltrendinouruniversityhospitalinordertoinduceanincreasinglytargetedempiricaltherapeuticapproachforthe treatment of UTIs. 1. Introduction Urinarytractinfections(UTIs)representwidespreadhuman microbial disorders involving any part of the urinary tract, suchasthekidneys,bladder,urethra,andprostate[1].UTIs arespreadallovertheworldwithabroaddirectandindirect socioeconomic impact in the global population. Further- more, these infections are associated with an important Hindawi International Journal of Microbiology Volume 2021, Article ID 5541706, 10 pages https://doi.org/10.1155/2021/5541706