Ahmed et al., 2022 JHE, 2022, 32(1): pp109 -121 . Printed in Menoufia University, Egypt. Copyrights © The JHE -109- Faculty of Home Economics Journal of Home Economics Menoufia University, Shibin El Kom, Egypt https://mkas.journals.ekb.eg Nutrition and Food Sciences Hyperglycemic Effect of Ropes Roots (Rehium Ribes) and Lemongrass Leaves (Cymbopogon Cittates) in Alloxan-Induced Diabetic Rats Adel A. Ahmed, Emad A. El-Kholie, Azza M. El-Eskafy and Nada Y. Darwish Department of Nutrition and Food Sciences, Faculty of Home Economics, Menoufia University, Shibin El- Kom, Egypt. Abstract Lemongrass and Rheum species are medicinal plants commonly consumed as a beverage for health and as a diabetes mellitus (DM) treatment in many countries. The primary purpose of this study was to study the effect of lemongrass leaves, ropes roots, and their mixture powder in lowering hyperglycemia in diabetic rats. Forty male albino rats weighing 140g±5g were divided into eight groups, each with five rats. Rats were given alloxan (150 mg/kg BWT) to make them diabetic. Glucose levels, total cholesterol, triglycerides, high-density lipoprotein (HDL-c), low-density lipoprotein (LDL-c), very low-density lipoprotein (VLDL-c), liver functions (ALT, AST, and ALP), and kidney functions (urea, uric acid, and creatinine) were also assessed. Results showed that the diabetic group had lower glucose levels and improved liver and kidney functions when fed a 5% combination, with significant differences (P≤0.05). Mixture plants had significantly lowest (P≤0.05) cholesterol and triglyceride levels and the lowest LDL-c and VLDL-c values. The group fed 5% mixed plants had the greatest amounts of HDL- c. The group fed 2.5 percent lemongrass had the lowest levels, with a significant difference (P≤0.05). In conclusion, diabetic rats given a 5% mixed powder showed significantly lower glucose levels and studied biochemical tests. Ropes, lemongrass powder, and their mixture could be utilized in our beverages, in addition to the other health benefits. Key words: Plant roots, Rats, Diabetic, Biochemical analysis. Introduction Diabetes mellitus is a class of metabolic illnesses marked by high blood glucose levels (hyperglycemia) caused by insulin secretion, insulin action, or both (1) . Diabetes is one of the most common chronic diseases in the world, impacting over 100 million individuals.