A Comparative Formulation Development and Evaluation of Tazarotene Ethosomal and Transfersomal Gel for E®ective Management of Acne Bera Piumitali * School of Pharmacy and Research, People's University Bhanpur, Bhopal, Madhya Pradesh 462037, India piumitali@gmail.com Upmanyu Neeraj † and Dubey Rupal ‡ School of Pharmacy and Research, People's University Bhanpur, Bhopal, Madhya Pradesh 462037, India † drneerajupmanyu@gmail.com ‡ rupaldubey03@gmail.com Pandey Arun Kumar Alkem Research and Development, C-17/7, MIDC Taloja Dist. Raigad, Navi Mumbai 410208, India Arun.pandey@alkem.com Received 10 January 2020 Accepted 11 March 2020 Published Acne vulgaris is the most prevalent disorder in the period before puberty when increased adrenal androgen level causes enlargement of the sebaceous glands and it increased the pro- duction of sebum on the face, chest, and back. This disease is caused due to interaction between many causative agents or pathogenic components which lead to formation of the acne and those are seborrhea, follicular hyper keratinization, microbial formation of pilosebaceous unit by Propionibacterium acne and arrival of in°ammatory mediators. Tazarotene is a well-known retinoid related to vitamin A that belongs to an acetylenic class of retinoid, used in the man- agement of acne. Oral administration of Tazarotene causes changes in bone morphology after prolonged exposure to high doses, which also exhibit teratogenicity but this does not occur with topical delivery. Ethosomes are non-invasive delivery carriers enabling drugs to reach to the bottom of the skin layers and/or the system and transfersomes are the self-adaptable ultra- deformable °exible elastic bilayer vesicles composed of phospholipids able to penetrate through the pores of skin even smaller than its size. Present research aims the comparative evaluation of ethosomal and transfersomal gels loaded with Tazarotene in the treatment of acne. In the present study, ethosomes and transfersomes were formulated by the cold method and hand- shaking method, respectively, followed by loading of Tazarotene and development into gel formulation. The formulated gel samples were evaluated for in vitro release study, in vitro permeation study, in vitro anti-acne study, in vivo percutaneous permeation study by CLSM, and in vivo anti-acne study. The results proved that both the formulated ethosomal and * Corresponding author. International Journal of Nanoscience Vol. 19, No. 4 (2020) 2050005 (23 pages) # . c World Scienti¯c Publishing Company DOI: 10.1142/S0219581X20500052 2050005-1 August 20, 2020 3:20:42pm WSPC/175-IJN 2050005 2nd Reading