This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process which may lead to differences between this version and the Version of Record. Please cite this article as doi: 10.1002/bmc.3782 This article is protected by copyright. All rights reserved. Pharmacokinetic Studies of a Novel Trioxane Antimalarial (99/411) in Rats and Monkeys by using LC-MS/MS  Running Title: Pharmacokinetics of 99-411 in rat and monkey Saurabh Pandey, #ab Nagsen Gautam, #ac Hari Narayan Kushwaha a and Shio Kumar Singh* a a Pharmacokinetics and Metabolism Division, Central Drug Research Institute, Lucknow, India. b School of Pharmacy, The University of Queensland, Brisbane, Australia c Dept. of Pharmaceutical Sciences, University of Nebraska Medical Center, NE, Omaha,USA. # Equal contribution  CDRI Manuscript No.: 135/2013/SKS *Corresponding author: Dr. Shio Kumar Singh, Pharmacokinetics and Metabolism Division, Central Drug Research Institute, Lucknow- 226 001 (INDIA); Fax: 91-522-223405/223938/229504; Phone: 91 522 262411 – 18 PABX 4389. E-mail: drshiokumar@gmail.com