Accepted Manuscript Design and Synthesis of A Biaryl Series As Inhibitors for the Bromodomains of CBP/P300 Kwong Wah Lai, F. Anthony Romero, Vickie Tsui, Maureen H. Beresini, Gladys de Leon Boenig, Sarah M. Bronner, Kevin Chen, Zhongguo Chen, Edna F. Choo, Terry D. Crawford, Patrick Cyr, Susan Kaufman, Yingjie Li, Jiangpeng Liao, Wenfeng Liu, Justin Ly, Jeremy Murray, Weichao Shen, John Wai, Fei Wang, Caicai Zhu, Xiaoyu Zhu, Steven Magnuson PII: S0960-894X(17)31113-7 DOI: https://doi.org/10.1016/j.bmcl.2017.11.025 Reference: BMCL 25431 To appear in: Bioorganic & Medicinal Chemistry Letters Received Date: 1 September 2017 Revised Date: 7 November 2017 Accepted Date: 13 November 2017 Please cite this article as: Lai, K.W., Romero, F.A., Tsui, V., Beresini, M.H., de Leon Boenig, G., Bronner, S.M., Chen, K., Chen, Z., Choo, E.F., Crawford, T.D., Cyr, P., Kaufman, S., Li, Y., Liao, J., Liu, W., Ly, J., Murray, J., Shen, W., Wai, J., Wang, F., Zhu, C., Zhu, X., Magnuson, S., Design and Synthesis of A Biaryl Series As Inhibitors for the Bromodomains of CBP/P300, Bioorganic & Medicinal Chemistry Letters (2017), doi: https://doi.org/ 10.1016/j.bmcl.2017.11.025 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.