© 2014 ACT. All rights reserved. Key words: Blood pressure; Uric acid; Oxidative stress; Physical exercise Jacomini AM, Zago AS. Understanding the Infuence of Oxidative Stress and Physical Exercise in the Relationship Between Blood Pressure and Uric Acid. Journal of Cardiology and Therapy 2014; 1(9): 221-227 Available from: URL: http://www.ghrnet.org/index. php/jct/article/view/943 INTRODUCTION Arterial Hypertension (HT) has been considered one of the main risk factors for cardiovascular diseases and, one of the biggest problems of public health [1-3] . Studies point for a prevalence above 30% within Brazilian adult population, which values increase even more with aging, reaching 50% between 60 and 69 years old and 75% in individuals above 70 years old [2] . These data are similar in Latin America countries [4] and United States [5] . With the increasing number of elderly population and the problems associated with aging, especially HT, there is a rising demand for health services [6] . In 2001, around 7.6 millions of deaths in the world were assigned to high blood pressure, which most of them are in Countries with low or medium economic development and most of individuals between 45 and 69 years old [2] . Because it is considered a chronic degenerative disease, HT has several factors involved in its etiology [2,7,8] , such as genetic and environmental factors, stress, poor diet, and others. However, it has been observed in several studies that, independently of the etiological factor, a large portion of hypertensive individuals present a hyperuricemia profile, which is considered a metabolic disorder marked by the excess of urate in blood. This number can reach about 25% [9-12] or, according to Heinig et al [12] who found that 89% of teenagers with essential HT presented uric acid (UA) concentrations upper to 5.5 mg/dL, whereas no one of the normotensive teenagers presented high levels of UA. Similar results were found by Assob André Mourão Jacomini, Faculty of Medicine, University of São Paulo, Ribeirão Preto, Brazil Anderson Saranz Zago, Department of Physical Education, UN- ESP, Univ Estadual Paulista, Bauru, Brazil Correspondence to: Anderson Saranz Zago, PhD, Department of Physical Education, UNESP, Univ Estadual Paulista, Av. Eng. Luiz Edmundo Carrijo Coube, 14-01, Bairro: Vargem Limpa, 17033-360, Bauru, SP, Brazil. Email: aszago@fc.unesp.br Telephone: +55-14-3103-6082 (Extension 7991) Received: September 30, 2014 Revised: November 20, 2014 Accepted: Novermber 22, 2014 Published online: December 10, 2014 ABSTRACT Due to the high incidence and prevalence of hypertension, especially in the elderly population, several studies have been developed to understand the relationship between etiological factors and blood pressure control. It has been demonstrated that hypertensive patients tend to present a status of hyperuricemia. This result suggested that there is a relationship between blood pressure and uric acid concentrations. However there is still a lack of studies that focus on this relationship, and especially how physical exercise could affect the relationship between both of them. Thus, the purpose of this study is to review and discuss the relationship between hypertension and uric acid concentration pointing the oxidative stress as the main factor of this relationship and discuss the physical exercise as the main preventive factor of high uric acid concentrations and oxidative stress. It has been described an increase in oxidative stress during the uric acid pathway because the high production of anions superoxide. This in turn, increases the activation of renin-angiotensin system and decreases nitric oxide bioavailability which will compromise the vasodilatation mechanism. However physical exercises have been associated with improvements in antioxidant capacity and nitric oxide production and bioavailability which will improve the blood pressure control. REVIEW Understanding the Influence of Oxidative Stress and Physical Exercise in the Relationship Between Blood Pressure and Uric Acid André Mourão Jacomini, Anderson Saranz Zago 221 © 2014 ACT. All rights reserved. Journal of Cardiol Ther 2014 December 10 1(9): 221-227 ISSN 2309-6861(print), ISSN 2312-122X(online) Online Submissions: http://www.ghrnet.org/index./jct/ doi:10.6051/j.issn.2309-6861.2014.01.57 Journal of Cardiology and Therapy