Fluid Phase Equilibria 362 (2014) 307–312 Contents lists available at ScienceDirect Fluid Phase Equilibria j ourna l ho me page: www.elsevier.com/locate/fluid Liquid–vapor equilibrium data of CO 2 + dichloromethane + medroxyprogesterone system W.M. Giufrida a , L.F. Pinto a , A.F. Zanette a , F.A.P. Voll b , M.H. Kunita c , V.F. Cabral a , L. Cardozo-Filho a,∗ a Department of Food Engineering, Universidade Estadual de Maringá, 87020-900 Maringá, PR, Brazil b Department of Chemical Engineering, Federal University of Paraná, 81531-980 Curitiba, PR, Brazil c Department of Chemistry, State University of Maringá, 87020-900, Maringá, PR, Brazil a r t i c l e i n f o Article history: Received 10 July 2013 Received in revised form 12 September 2013 Accepted 16 October 2013 Available online 30 October 2013 Keywords: Phase equilibrium Supercritical fluid Carbon dioxide Medroxyprogesterone a b s t r a c t In this work the vapor–liquid equilibrium for the {CO 2 (1) + dichloromethane(2) + medroxyprogesterone (3)} system were measured for different concentrations of medroxyprogesterone in dichloromethane (0.01 g mL -1 and 0.02 g mL -1 ) at temperatures ranging from (303 to 333) K and pressure up to 8.6 MPa. The experimental data were obtained using a visual synthetic static method employing a variable volume cell. The liquid–vapor transitions were classified as a bubble points and dew points in the presence or absence of solid phase. The experimental vapor–liquid equilibrium data were satisfactory correlated using the Peng–Robinson equation of state with a quadratic mixing rule. © 2013 Elsevier B.V. All rights reserved. 1. Introduction The production of particles with controlled size and distribution size has been target of many researches that develop nanoparticles (NPs) of different compounds, which are used as active principles in formulations employed at pharmaceutical, food, cosmetic, and veterinarian industries [1]. In such applications, the particle size is a key factor to the proper development and the use of differ- ent organic and inorganic materials [2]. The medoxyprogesterone acetate (MPgAc) is a progestin molecule (synthetic modification of the progesterone molecule) that has many pharmacological actions over the endocrine system. Among the main actions of MPgAc, we can cite the inhibition of pituitary gonadotropins, level reduction of adrenocorticotropic hormone (ACTH) and hydrocortisone in the blood, reduction of current testosterone and estrogenic levels [3]. Oral or parenteral administration of MPgAc (in the recommended dose), in women with adequate endogenous estrogen, transforms the proliferative endometrium in secretory. When the parenteral route is used, the gonadotropin production is inhibited. In this way, the follicular maturation and ovulation are prevented. Such phe- nomenon does not occur when the oral dose is administered one ∗ Corresponding author. Tel.: +55 44 30114749; fax: +55 44 30114749. E-mail addresses: cardozo@deq.uem, cardozo@deq.uem.br (L. Cardozo-Filho). time a day [4]. The MPgAc can be also used in the endometriosis treatment and in the reduction of vaginal lubrication. Supercritical fluid (SF) technologies are becoming an important alternative to conventional methods in many fields like extraction, particle micronization, process of materials and chromatograph or crystallization/purification [5]. Equilibrium data and volumet- ric properties of binary mixture containing an organic solvent and a SF, especially carbon dioxide (CO 2 ), play a vital role in many of those applications. The vapor–liquid equilibrium and liquid density are necessary data for develop properly the precipita- tion/recrystallization process using the antisolvent gas technique [6]. In this technique, the solid phase can be produced with unique morphology at mild conditions of operation. The CO 2 is an inter- esting solvent from an industrial viewpoint because of its low cost, non-flammability, non-toxicity and miscibility in many organic sol- vents. Recently, the use of CO 2 as antisolvent in the crystallization of dissolved solutes has grown largely. The organic solvent choice in a process that uses the antisolvent technique is a crucial fac- tor in the control of solute solubility, morphology and particle size [7]. Moreover, for correct application of supercritical CO 2 as anti- solvent for the production of NPs, it is necessary the knowledge of the phase behavior of a solute + organic solvent + CO 2 system. In this context, this work presents the vapor–liquid equilibrium data of MPgAc + Dichloromethane + CO 2 system in different condi- tions of pressure, temperature and system mole fractions. Here, the phase transitions were identified as a bubble point (BP) and dew 0378-3812/$ – see front matter © 2013 Elsevier B.V. All rights reserved. http://dx.doi.org/10.1016/j.fluid.2013.10.037