PO263 Choice In Blood Pressure Lowering Drug Therapy – An Analysis of the Availability of Different Drugs and Doses Over the Last 40 Years R. Kanukula* 1 , A. Salam 1 , E. Atkins 2 , K. Rogers 3 , A. Rodgers 2 1 Cardiovascular, The George Institute for Global Health, Hyderabad, India, 2 Cardiovascular, 3 Statistics, The George Institute for Global Health, Syndney, Australia Introduction: Clinical guidelines emphasize the importance of individualising blood pressure (BP) lowering therapy, which requires access to different drugs at different strengths. To date there has been no quantification of the degree of choice in BP lowering drugs, nor trends over time. Objectives: To quantify the degree of choice in antihypertensive drugs and doses over time in the USA. Methods: Approvals of antihypertensives and their combinations in the form of tablet and/ or capsule were searched in United States Food and Drug Administration (FDA) Orange book.url and dates of search. Data were reported descriptively as frequencies, percentages and mean. Results: Until July 2017 the FDA had approved 86 new chemical entities (NCEs) in 272 strengths (average 3.2 per NCE). There were 59 dual and four triple combinations approved in 155 and 16 strengths (average 2.7 and 4.0 per combination), respectively. Only three NCEs, 10 dual and three triple combinations have been approved in last decade. A total of 46 products had been discontinued as of July 2017, leaving 65 NCEs, 35 dual and two triple combinations on the market. The possible number of unique combinations for commonly recommended dual combinations considering dose variations were nearly 6 million (excluding contra-indicated combinations). Conclusion: There is a very high degree of choice in BP lowering drugs. Further research is required to assess whether this degree of choice has had the unintended consequence of increasing prescriber switching between drugs and displacing more effective treatment intensification strategies, such as adding blood pressure drugs. Disclosure of Interest: None declared PO264 Sodium Composition of Vended Rice Dishes At a Major Market In Enugu Metropolis Compared With Dietary Approach to Stop Hypertension Sodium Recommendation R. C. Anakwue* 1 , A. Maduforo 2 , E. Young 3 , C. Ndiokwelu 4 , C. Okoli 5 , C. Ezenduka 5 , I. Nnabuike 6 , D. Ibegbu 7 , on behalf of HYPERTENSION AND DIABETES RESEARCH GROUP UNIVERSITY OF NIGERIA 1 Dept of Medicine, Pharmacology/Therapeutics, 2 Nutrition and Dietetics, 3 Dept of Medicine, University of Nigeria, Enugu, 4 Nutrition and Dietetics, Dept of Biochemistry, university of Calabar, Calabar, 5 Dept of Health Administration and Management, 6 Dept of Chemical Pathology, 7 Dept of Biochemistry, University of Nigeria, Enugu, Nigeria Introduction: Rice is a common staple food consumed in Enugu state and it is cooked in different forms to diversify its use. Dietary Approaches to Stop Hypertension (DASH), eating pattern is a total diet plan based which included reduced intake of salt. Consumption of salt (sodium), and other dietary factors are thought to have play an important etiologic role in primary hypertension in genetically predisposed individuals. Objectives: The study determined the sodium content of rice dishes vended in a major market in Enugu metropolis and compared the sodium content per serving portion to one third of DASH sodium recommendation per day. Methods: Each rice dish sample was collected using stratified sampling technique from five different vendors at different locations. The rice dishes sampled were jollof rice, tomato stew + white rice, fried rice, white rice + sauce and white rice + ofeakwu. Each type of rice dish sampled from different vendors was homogenized and sampled in triplicatedfor sodium analysis. The sodium content was determined using spectro- photometric method in the Chemistry laboratory of Biochemistry Department of University of Nigeria Nsukka. The result of triplicate samples was subjected to sta- tistical analysis using analysis of variance (ANOVA) to compare the sodium of the five samples and turkey HSD was used for Post Hoc analysis. A one sample t-test was used to compare the mean values with one third of DASH sodium recommendation per day. Results: Tomato stew with boiled white rice significantly (p< 0.05) contained the highest (2197.25 mg/portion size) sodium and boiled white rice with vegetable sauce significantly (p < 0.05) contained the least (1085.64 mg) sodium among all the rice dishes sampled in the study. Mean sodium content per portion of rice dishes were 1583.07 mg. The sodium content of all the rice dishes were significantly (p < 0.05) higher that than DASH rec- ommendation.A one sample t-test, revealed that the mean sodium content of rice dishes was significantly (t ¼ 7.747; df ¼ 14; p ¼ 0.000) higher than DASH sodium recom- mendation as well. Conclusion: Vended rice dishes contained very high sodium which is a risk factor for hypertension. Disclosure of Interest: None declared PO265 Arterial Stiffness,Central Blood Pressures and Microalbuminuia Reduction With Barnidipine and Enalapril In Obese, Hypertensive and Diabetic Patients. A Pilot Study R. M. Cabrera-Solé* 1 , L. Urrego Rivera 1 , J. Cañas Gonzalez 1 , S. Garcia Ruiz 1 , C. Turpin Lucas 1 1 Cardiology., General University Hospital of Albacete. Spain.European Union., Albacete, Spain Introduction: At the present time, we have the arterial stiffness index (ASI) central blood pressures (cSBP, cDBP) and microalbuminuria (mcALB) to evaluate hypertensive patients (HTA-P) risk. These parameters allows us to clearly identify those P with higher risk. However, it is not possible to study the effects of the different drugs on these factors. In this study we evaluate the effects on the risk factors of a third-gen- eration calcium-antagonist, barnidipine ( BNP), and to angiotensin enzyme inhibitor, enalapril (ENL). Objectives: To evaluate the effect of the combination of BNP and ENL on arterial stiffness, central pressures and microalbuminuria on obese and diabetic untreated hypertensive patients. Methods: Prospective study and follow-up at 12 months, including 123 HTA-P (68 Æ 8 years, 25 women), referred from health centers, who were made at the beginning and end of the study, a measurement of the ASI by the rate of augmentation index (AI), pulse wave velocity (PWV) and central blood pressures systolic and diastolic (cSBP,cDBP). All of them received, in addition to their antidiabetic treatment, a com- bination of BNP + ENL to maintain blood pressure below 130/80 mmHg. Results of the beginning and the end of the study were compared and we show them below. Results: Conclusion: According to our data, the combination of BNP + ENL is an excellent alter- native to reduce central pressures as well as arterial stiffness in hypertensive, obese and diabetic patients, which we must take into account when selecting our treatments in this group of patients with high cardiovascular risk. Disclosure of Interest: None declared TABLE OF RESULTS: DATA cSBP cDBP mcALB AI PWV BASELINE 112Æ2 92Æ2 29Æ5 32Æ5 9Æ3 FINAL 97Æ3* 79Æ3* 24Æ10 19Æ4* 6Æ4* *means value p <0.05. 438 GHEART Vol 13/4/2018 j December, 2018 j POSTER/2018 WCC PO003-PO653 POSTER ABSTRACTS