Journal of Aquaculture and Fish Health Vol. 10(1) - February 2021 DOI : 10.20473/jafh.v10i1.18234 Prajayati et al. (2021) 9 The Digestion Level of Tilapia (Oreochromis niloticus) to Different Feed Combination Vini Taru Febriani Prajayati 1,2* , Otie Dylan Subhakti Hasan 3 and Mugi Mulyono 4 1 Aquaculture Technology Study Program, Postgraduate of Sekolah Tinggi Perikanan Jakarta, Jl. AUP 1, Kec. Ps. Minggu, Jakarta Selatan, Daerah Khusus Ibukota Jakarta 12520, Indonesia 2 Pangandaran Marine and Fisheries Polytechnic, Jalan Raya Babakan KM.2, Babakan, Pangandaran, West Java 46396, Indonesia 3 Fisheries Counselling, Sekolah Tinggi Perikanan Bogor, Jalan Kapten 12 Pasir Jaya, Bogor, West Java 16119, Indonesia 4 Aquaculture Technology, Sekolah Tinggi Perikanan Jakarta, Jalan AUP 1, Pasar Minggu, Jakarta Selatan, Daerah Khusus Ibukota Jakarta 12520, Indonesia Abstract Digestibility is food substances from feed consumption that are not excreted into the feces, and the difference between food substances consumed and those excreted in the feces is the amount of food that can be digested. Information about the digestibility value of food is very important as a basis in assessing the quality of food and designing fish feed rations. This research was conducted to determine the level of the feed digestibility in nirvana tilapia (Oreochromis niloticus) feed with a combination of fish meal and maggot flour. This research was conducted at the Hatchery Campus of BAPPL STP Serang, Banten from September-December 2019. This study used a Completely Randomized Design (CRD) with 5 treatments and 3 replications. There were 225 fish used in the testing with an average weight of 0.16 grams. The culture media used was a plastic container with a size of 60 x 41 x 34 cm. Feeding was carried out for 50 days, with a frequency of twice a day, and the dose of feeding was 3% of the biomass. The results showed the total digestibility parameter of feed, protein digestibility of feed and the highest protein retention in the treatment of 50% of the combination feeds , with the highest total digestibility value of 56.97 ± 3.41 and the lowest of 42.08 ± 0.42, the highest protein digestibility with a value of 87.33 ± 0.95and the lowest of 83.11 ± 1.30 and the highest protein retention with a value of 14.83 ± 0.22and the lowest of 11.69 ± 1.05. INTRODUCTION Tilapia is one of the freshwater fish that has important economic value and has several benefits when compared to other freshwater fish; it has fast growth, is easy to maintain in various culture media, has high resistance to extreme environments, and has high nutritional value (Murni, 2013; Shofura et al., 2017). Feed is one of the most important factors in tilapia culture. Artificial feed is feed made with certain formulations according to the needs of the fish being kept (Wicaksono et al., 2013). Fish feed formulations generally still use fish meal as a source of protein, but at this time local fish meal is only able to meet 60-70% of feed needs which fluctuates in their quality and quantity (Prayogo et al., 2012; Marno et al., 2016). One of the local raw materials that can *Correspondence : vinitapasca18@gmail.com Received : 2020-03-12 Accepted : 2020-07-13 Keywords : Tilapia, Total digestion, Protein digestion, Protein retention