DOI: https://doi.org/10.53350/pjmhs22161898 ORIGINAL ARTICLE 898 P J M H S Vol. 16, No.01, JAN 2022 Prevalence of Diabetic Neuropathy in Diabetic Type II Patients from Khyber Pakhtunkhwa LIHAZ GUL 1 , NADEEM SHARIF 2 , SAJJAD MOHAMMAD 3 , BADI UDDIN 4 , ZAHID KHAN 5 , ABID RAHIM 6 1 Clinical Technologist, Department of Pathology, Hayatabad Medical Complex, Peshawar, Pakistan. 2 PhD scholar, Department of Medical Laboratory Technology, University of Haripur, Pakistan. 3 Associate Professor, Department of Physiology, Jinnah Medical College, Peshawar, Pakistan. 4 Senior Clinical Technician, Department of Pathology, Mardan Medical Complex, Mardan, Pakistan. 5 Assistant Professor, Institute of Chemistry Sciences, University of Peshawar, Pakistan. 6 *Lecturer, Sardar Begum Dental College and Hospital, Peshawar, Pakistan. Corresponding author*: Dr. Abid Rahim, Email:abidrahim@asia.com ABSTRACT Introduction: Diabetic neuropathy is the main cause of neuropathy and major complications of diabetes mellitus throughout the world. This may lead to incapacity and amputations due to severe diabetes. The morbidity and mortality rates increase in diabetes due to severe neuropathy. The present study was aimed to determine the prevalence of diabetic diabetic neuropathy in diabetic mellitys type II affected patients. Materials and Methods: This research took place in Peshawar from September 2019 to January 2020. A total of 205 blood samples were collected from diabetic patients with type II diabetes, both neuropathic (n=105) and non - neuropathic (n=100). Blood samples were taken in order to estimate random blood sugar levels (RBS). Results: The age group 50-55 years had the highest percentage of cases (66.8%), followed by 56-60 years (21.5%), and 61-65 years (5.5%). Female patients were more likely than male patients to have diabetes, both neuropathic (62.9 percent) and non-neuropathic (58 percent). The predominance of neuropathic and non- neuropathic diabetes patients involved in this study because it was undertaken in Peshawar.(50.2 percent). Conclusion: It is concluded that female were more prone to diabetes both with neuropathy and without neuropathy. Keywords: Prevalence, Diabetes, Neuropathy, Diabetic mellitus type II, INTRODUCTION Diabetes neuropathy is the most frequent complication among diabetics, and it is responsible for a high rate of death and morbidity, as well as a significant expense of health care 1 . Neuropathy is defined as a damage to a peripheral nerve that starts in the nerve and progresses to the toes 2 . This injury causes pain, tingling, burning, and other uncommon symptoms including numbness, loss of balance, inability to perceive toe position, loss of warmth, and loss of touch sensitivity in the legs and feet 3 . Impotence, heart issues, kidney disorders, vision impairment, and amputation are some of the other consequences that can cause a major decline in quality of life 4 . Diabetic neuropathy has become more common over time as a result of poor glucose control 5,6 . Diabetic neuropathy is a worldwide affliction that affects millions of individuals. It's also becoming more of an issue in places where obesity is widespread. Although the most prevalent clinical signs of diabetic neuropathy were found in the mid-nineteenth century, our knowledge of the condition has recently improved 7 . As a result of inadequate glucose management, diabetic neuropathy has become increasingly frequent over time 8 . T1DM can develop to severe diabetic polyneuropathy in a matter of months if it is not effectively treated after start in young adults 9 . After some weeks, a small number of people with diabetes develop "multifocal diabetic neuropathy," that impacts the nerves and roots of the trunk, lower and upper extremities. Further to that, "unilaterally or bilaterally," the distal area of the lower extremities is sometimes regularly implicated, and proximal inadequacies are also present in significant patients 10 . PDN can be very painful, and "traditional therapies" are typically useless. In such cases, treatment with "corticosteroids" for a few weeks or months, combined with glycemic control adjustment, is a good idea. It's vital to recall that focused "diabetic neuropathies" have a usually good "spontaneous prognosis" 11 . However, no research has been done to assess if diabetes control has improved in our clinical context over time as knowledge of the disease pathophysiology has increased. As a result, the purpose of our study was to find out how common diabetic neuropathy is in Khyber Pakhtunkhwa. MATERIALS AND METHODS Between October 2019 and March 2020, a six-month descriptive comparative cross-sectional research was conducted. The study was conducted at Hayatabad, Peshawar, at the University of Peshawar's Chemistry Department and the Hayatabad Medical Complex Hospital's Biochemistry Section. Patients suspected of having diabetes were initially tested and diagnosed with type 2 diabetes. All of these patients, both with and without neuropathy, had their folic acid levels tested. A total of 205 samples were collected, with 105 and 100 samples acquired from known type 2 diabetes mellitus patients with diabetic neuropathy and without neuropathy, respectively, as a control group. The ethics committees of the University of Peshawar and the Hayatabad Medical Complex Hospital in Peshawar approved the study. Following the approval of the study by the ethics committee, all patients provided both oral and written consent. This study included patients with type 2 diabetes mellitus (T2DM), regardless of gender or age. Individuals with Type 1 diabetes, pregnant women with