|| ISSN(online): 2589-8698 || ISSN(print): 2589-868X || International Journal of Medical and Biomedical Studies Available Online at www.ijmbs.info NLM (National Library of Medicine ID: 101738825) Index Copernicus Value 2019: 79.34 Original Research Article Volume 5, Issue 8; August: 2021; Page No. 183-187 183 | Page COMPARATIVE STUDY OF SERUM CALCIUM, MAGNESIUM, URIC ACID AND GLUCOSE IN PREECLAMPSIA AND NORMAL PREGNANT WOMEN OF MALWA REGION OF MADHYA PRADESH Dr Darshna Jain 1 , Dr. Mohit Kulmi 2 , Dr Prachi Paliwal 3 , Dr Manoj Narayan Paliwal 4 1 Assistant Professor, Biochemistry, Govt. Medical College Ratlam, (MP) 2 Assistant Professor, Department of Pharmacology, Govt. Medical College Ratlam, (MP) 3 Associate Professor, Biochemistry, SAIMS, Indore, (MP) 4 Professor, Biochemistry, Govt. Medical College Ratlam, (MP) Article Info: Received 16 June 2021; Accepted 06 August 2021 DOI: https://doi.org/10.32553/ijmbs.v5i8.2108 Corresponding author: Dr. Mohit Kulmi Conflict of interest: No conflict of interest. Abstract Background: Comparative study of serum calcium, magnesium, uric acid and glucose in preeclampsia and normal pregnant women of malwa region of Madhya pradesh Methods: For the Study, a total of 100 women ranging in age from 18-35 years were recruited. They were divided in two groups. 50 were pre-eclamptic women with gestational age of ≥20 weeks (Case group) and rest 50 were normal pregnant women of same gestational age (Control group).The levels of magnesium, calcium, glucose, and uric acid in the blood were measured. Result: Serum calcium and magnesium levels were significantly lower (p<0.001) in the pre-eclamptic group, whereas serum uric acid levels were significantly higher (p0<001) in preeclamptic group. The level of serum glucose was raised in preeclampsia. Conclusion: serum levels of calcium, magnesium, uric acid and glucose are altered in pre-eclampsia, implying that these factors may play a role in the aetiology and severity of pre-eclampsia.so assessing the serum level of this parameters will aid in the early detection of pre-eclampsia. Keywords: Calcium, Magnesium, Uric acid, Glucose, Pre-eclampsia, Pregnancy Introduction Around 10% of all pregnant women in the world suffer from hypertensive disorders of pregnancy (1). hypertensive disorders of pregnancy include pre-eclampsia and eclampsia, gestational hypertension and chronic hypertension (2).Pregnancy-related hypertensive conditions are a leading cause of extreme acute morbidity, long-term impairment, and death in mothers and infants. (3)Pre- eclampsia is unique among hypertensive disorders in terms of the effects it has on maternal and neonatal health. It is a leading cause of maternal and perinatal mortality and morbidity around the world (4).It affects 4-8 percent of all pregnancies. (5).Preeclampsia is a leading cause of maternal mortality in developing countries with inadequate access to health care, with estimates of >60,000 maternal deaths each year (6).According to WHO‟s World Health Report 1998, Preeclampsia is defined as “the development of hypertension (>140/90mm of Hg) after 20 weeks of pregnancy in awoman with proteinuria with or without edema and without previous history of hypertension” (7).Visual abnormalities, oliguria, eclampsia, hemolysis, elevated liver enzymes, thrombocytopenia, pulmonary oedema, and foetal growth restriction are all possible complications (8).The pathophysiological process is characterized by trophoblastic invasion failure of the spiral arteries, which may be linked to increased uterine artery vascular resistance and decreased placental perfusion. (9).Recent research has found a connection between hypertensive complications and changes in the concentration of various biochemical parameters in pre- eclamptic women, such as serum uric acid, calcium, and magnesium.Calcium is essential for muscle contraction as well as for control of water balance in cell. A change in plasma calcium concentration leads to the alteration of blood pressure. The decreased serum calcium and the increased intracellular calcium can cause an elevation of blood pressure in preeclamptic mothers (10,11). The serum magnesium also decreases in women with pre-eclampsia (10).Magnesium has long been recognized as an essential cofactor in a variety of enzyme systems.In addition to changes in serum calcium and magnesium levels, pre- eclampsia causes a rise in uric acid levels. Reduced renal excretion as a result of pre-eclampsia, increased tissue degradation, acidosis, and an increase in the activity of the xanthine oxidase/dehydrogenase enzyme are all proposed mechanisms for the increase in uric acid in pre-eclampsia (12).As a result, preeclampsia could be caused by changes in calcium, magnesium, and uric acid metabolism during pregnancy.It has been documented that preeclampsia can occur in women who have gestational diabetes mellitus (13).The aim of this study was to compare and quantify