JOURNAL OF NATURAL REMEDIES DOI: 10.18311/jnr/2022/30831 Article Received on: 27.09.2022 Accepted on: 26.10.2022 Revised on: 20.10.2022 1. Introduction Te relationships between man and plants have been much closer during the evolution of human culture. Nature has given us a vast supply of cures for every disease that afects people. Herbal drugs have been in use for ages and are thus a valuable and precious gif from nature. India’s traditional systems of medicine (Ayurveda and Siddha) are deeply rooted in the Indian psyche. Plants continue to be one of the primary sources of medications in both the traditional and modern systems of medicine around the world, despite the enormous advancements made in the feld of allopathy during the 20 th century 1 . Because of increased awareness about the toxicity and side efects of synthetic medications, interest in the research and usage of crude drugs has signifcantly expanded during the past 20 years. Active phytoconstituents like favonoids, terpenoids, polyphenols, tannins, glycosides, alkaloids, steroids, etc. are responsible for therapeutic action. Generally, most of the phytoconstituents are polar in nature and hence face hurdles when crossing biological membranes. Te inability of phytoconstituents to dissolve in lipids and their larger molecular structure restrict their absorption via the cell membrane. Conventional therapy used in traditional systems includes various dosage forms like decoction, churna, vati, bhasma etc., and have the main drawback of patient non-compliance 2 . It is challenging to take the drug orally because of its bitter taste as well as its interaction with gastric juice. A number of constituents of the plant do not survive the gastric environment when taken orally. Many of the herbal extracts and active constituents show admirable activity during in vitro studies, but in in vivo set up, they have been found to display lesser or no therapeutic activity because of their polar nature, molecular size, or both, which results in poor absorption and ultimately lack of bioavailability of active constituents 3 . Te potency of a drug depends mainly on the efective delivery of phytoconstituents. So, the urge to integrate modern pharmaceutical knowledge with conventional delivery of herbal drugs to overcome these barriers. Novel drug delivery systems enhance the bioavailability, stability and therapeutic efect of natural products. Numerous novel herbal vesicular delivery systems have been fruitfully developed in recent years, including liposomes, phytosomes, niosomes, tansferosomes, ethosomes and various other vesicular systems to meet the challenges. Drug targeting and the sustained release of the active molecule are made possible by vesicular drug delivery systems 4 . Te novel delivery system known as phytosomes was invented in Italy by Indena. Phytosomes are also known as phyto-vesicles, herbosomes, or planterosomes, and they improve the absorption of natural extracts and active plant REVIEW ARTICLE Phyto Vesicular Drug Delivery System: A Review Kinjal Bera * and Madhavi Patel Department of Pharmacognosy, Parul Institute of Pharmacy, Parul University, Limda, Vadodara - 391760, Gujarat, India; kinjal_savani@yahoo.com Abstract Natural phytoconstituents face challenges in exploring the in vivo effect despite having enormous in vitro therapeutic potential because of their low solubility and large complicated structures. To get over these obstacles, the phyto vesicular combination comprising phytoconstituents and phospholipid complex is effective. This review offers details on the phyto-vesicular complex, including information on the types of phytoconstituents and phospholipids, solvents, ratios of phytoconstituents to phospholipids, and evaluation factors. The review compiles information on a few medicinal plants and their active ingredients, from which phytosomes are formulated and evaluated. Keywords: Herbal Extracts, Phospholipids, Phytoconstituents, Phyto Vesicular Complex