How to Cite: Pandya, M. K., Panchal, A., Khan, F. A., Pandya, R. K., & Khandhadia, D. (2022). Evaluating antimicrobial efficacy of bovine colostrum in patients suffering from periodontal disease: An invitro study. International Journal of Health Sciences, 6(S3), 11042–11050. https://doi.org/10.53730/ijhs.v6nS3.9257 International Journal of Health Sciences ISSN 2550-6978 E-ISSN 2550-696X © 2022. Manuscript submitted: 18 Feb 2022, Manuscript revised: 27 April 2022, Accepted for publication: 9 June 2022 11042 Evaluating antimicrobial efficacy of bovine colostrum in patients suffering from periodontal disease: An invitro study Maitri Ketan Pandya Post Graduate Student, College of Dental Sciences and Research Centre, Manipur, Ahmedabad, India *Corresponding author email: pandyamaitri1996@gmail.com Anita Panchal Professor& HOD, College of Dental Sciences and research centre, Manipur, Ahmedabad, India Faizan Ather Khan Post Graduate Student, College of Dental Sciences and Research Centre, Manipur, Ahmedabad, India Rachana K. Pandya Post Graduate Student, College of Dental Sciences and Research Centre, Manipur, Ahmedabad, India Dinesh Khandhadia (M.Sc. {Medical}, Fellow Researcher, Gujarat University), Ph. D. Scholar, Micro-Aid Diagnostic Laboratory, Ahmedabad, India Abstract---Purpose: Bovine Colostrum is the first milk, a mammary secretion produced by all cows for their babies during the first 24–48 hours after birth. Bovine Colostrum contains immunoglobulins and lactoferrin that help in bactericidal and bacteriostatic effects against microorganisms. The purpose of this study is to evaluate the efficacy of bovine colostrum at different concentrations in patients suffering from chronic periodontitis. Methodology: Plaque and calculus samples were obtained from 15 patients aging from 30 - 60 years. The collected samples were then poured on agar plates and different strains of Gram -ve bacteria were obtained. The streak plate method was adopted. For the anti-microbial susceptibility test, a solution of Bovine Colostrum Powder was prepared in Dimethyl sulfoxide (DMSO) at various concentrations (50 µg/ml, 100 µg/ml, and 200 µg/ml). Result: A minimal zone of inhibition was seen at 50 µg/ml with a mean of 3.8. Proper inhibition zones were seen in 100 µg/ml and 200 µg/ml with