Pharmacia: An Int. J. of Pharm….Sci. 2016, 3 (1): 171-178 Page 171 PREPARATION AND CHARACTERIZATION OF SELF EMULSIFYING DRUG DELIVERY SYSTEM OF TELMISARTAN Manoj Goyal* 1 , Vikas Rathore 2 , Ashutosh Dubey 3 1,2,3 IPS college of Pharmacy, Gwalior, India ABSTRACT Improvement of bio-availability of poorly water soluble drugs presents one of the further most challenges in drug formulations. One of the most admired and commercially viable formulation approaches for this challenge is self emulsifying drug delivery system (SEDDS). There are many techniques to convert liquid SEDDS to solid, but an adsorption technique is simple and economic. Hence aim of present study was to develop SEDDS of poorly water soluble drug Telmisartan (TEL) using Aerosil 200 as solid carrier. Liquid SEDDS was prepared using Acrysol EL 135, Tween 80 and PEG 400 as oil, surfactant and co-surfactant and was converted to SEDDS by adsorbing it on Aerosil 200. Prepared SEDDS was evaluated for flow properties, drug content, reconstitution properties, DSC, SEM, in-vitro drug release and ex- vivo intestinal permeability study. Results showed that prepared SEDDS have good flow property with 99.45 ± 0.02% drug content. Dilution study by visual observation showed that there was spontaneous micro emulsification and no sign of phase separation. Droplet size was found to be 0.34 μm with polydispersity index of 0.25. DSC thermogram showed that crystallization of TEL was inhibited. SEM photograph showed smooth surface of SEDDS with less aggregation. Drug releases from SEDDS were found to be significantly higher as compared with that of plain TEL. Ex-vivo intestinal permeability study revealed that diffusion of drug was significantly higher from SEDDS than that of suspension of plain TEL. Study concluded that SEDDS can effectively formulated by adsorption technique with enhanced dissolution rate and concomitantly bioavailability. Keywords: Telmisartan, SEDDS, solubility enhancement, ternary phase diagram, bioavailability. Corresponding Address Dr. Manoj Goyal Associate Professor IPS college of Pharmacy, Gwalior, (India) Available Online at www.pharmacia.ipsgwalior.org ISSN. No. 2229-4309 (Online), Vol. 3, Issue 1, July 2016 Pharmacia: An International Journal of Pharmaceutical Sciences RESEARCH ARTICAL