Journal of Biosciences and Medicines, 2021, 9, 118-123 https://www.scirp.org/journal/jbm ISSN Online: 2327-509X ISSN Print: 2327-5081 DOI: 10.4236/jbm.2021.912010 Dec. 22, 2021 118 Journal of Biosciences and Medicines A Severe COVID-19 Infection in Neonates: A Case Report Idrissa Demba Ba 1,2* , Mohameth Mbodj 1 , Fatim Tall 1 , Serigne T. Ndiaye 1 , Safietou Dieye 1 , Mouhamed Fattah 1 , Amadou Sow 1,3 , Ndeye F. Sow 1 , Awa Kane 1 , Aita Seck 1 , Aminata Mbaye 1 , Alioune M. Coundoul 1 , Khadim Bop 1 , Pape S. Sow 1 , Amadou L. Fall 1,2 , Papa M. Faye 1,2 , Ousmane Ndiaye 1,2 1 Albert Royer National Children Hospital, Dakar, Senegal 2 Cheikh Anta DIOP University, Dakar, Senegal 3 Abass Ndao Hospital Center, Dakar, Senegal Abstract Coronavirus disease (COVID-19) is a highly contagious infectious disease. First case was reported at the end of 2019 in China. Children and neonate population appears to be relatively free of the virus. We reported a severe and fatal neonate case of COVID-19 in a 22 days old neonate female due to the delta variant strain during the third wave outbreak. She presented with fever, cough, grunting and diarrhea started 5 days before admission. Physical ex- am’s revealed severe respiratory distress, hypoxia and bilateral pulmonary condensation. PCR test for COVID-19 was positive. Chest X-ray found bila- teral infiltrates. Chest CT showed diffuse ground glass images with 75% of lung parenchymal involvement. She was treated with antibiotics, corticostoid, respiratory support (CPAP and oxygen). Death occurred after 15 days of hos- pitalization in the context of multiple organ failure and pulmonary hyperten- sion. Keywords COVID-19, Hypoxia, Newborn, Variant Delta, Senegal 1. Introduction In December 2019, there was an outbreak of an infectious disease in Wuhan in the Hubei Province of China, called Coronavirus disease 2019 (COVID-19) [1]. COVID-19 is highly contagious disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). How to cite this paper: Ba, I.D., Mbodj, M., Tall, F., Ndiaye, S.T., Dieye, S., Fattah, M., Sow, A., Sow, N.F., Kane, A., Seck, A., Mbaye, A., Coundoul, A.M., Bop, K., Sow, P.S., Fall, A.L., Faye, P.M. and Ndiaye, O. (2021) A Severe COVID-19 Infection in Neonates: A Case Report. Journal of Bio- sciences and Medicines, 9, 118-123. https://doi.org/10.4236/jbm.2021.912010 Received: October 10, 2021 Accepted: December 19, 2021 Published: December 22, 2021 Copyright © 2021 by author(s) and Scientific Research Publishing Inc. This work is licensed under the Creative Commons Attribution International License (CC BY 4.0). http://creativecommons.org/licenses/by/4.0/ Open Access