Submit Manuscript | http://medcraveonline.com In a cross-sectional study of 900 cases of patients with obesity grades 2 and 3, we showed that the time of onset of weight gain in women was fundamentally related to pregnancy, menopause and emotional situations, while in men smoking cessation and a decrease in physical sports activity predominated. 4 Likewise, a study of psychological afectation and multiscale quality of life in the same population showed greater overall afectation and of any subscale in obese women compared to men. 5 As in the case of most heterogeneous diseases, the etiology is obviously multifactorial, where genetic predisposition and the environment, through epigenetic changes and other mechanisms, can favor its appearance. Hormonal variations, emotional factors, concomitant medications, lifestyle and a long etcetera operate here to give rise to a specifc clinical phenotypic outcome with its risks and comorbidities. Thus an etiological identifcation is important to establish a comprehensive individualized treatment (Figure 1). Adv Obes Weight Manag Control. 2021;11(5):155‒157. 155 ©2021 Vázquez et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and build upon your work non-commercially. Obesity in postmenopausal women: causes, prevalence and specifc risks: role of decreased resting energy expenditure Volume 11 Issue 5 - 2021 Clotilde Vázquez, 1–3 Bogdana L Luca, 1 Jersy Cárdenas, 1,2 Alvaro Sanchez, 1,4 Teresa Montoya, 2 Paula Labeira, 1,4 Belen Gutierrez, 1,4 Yvonne Fernandez, 1 Roberto Sierra, 1,3 Diego Meneses 1 1 Department of Endocrinology and Nutrition, Fundación Jiménez Díaz University Hospital, Spain 2 Infanta Elena University Hospital, Spain 3 Villalba General University Hospital, Spain 4 Medicadiet, Spain Correspondence: Clotilde Vázquez, Department of Endocrinology and Nutrition. Overweight and Obesity Unit. Fundación Jiménez Díaz University Hospital, Spain, Email Received: September 20, 2021 | Published: October 05, 2021 Advances in Obesity, Weight Management & Control Review Article Open Access Causes and differential consequences of overweight and obesity in women All epidemiological studies relating mortality to Body Mass Index (BMI) in adults up to 80 years show the typical U-curve, with the minimum mortality around BMI of 22 in both sexes, an abrupt increase in mortality when BMI is below 18, and a steady increase in mortality when BMI exceeds 28. According to a major prospective study involving 900 000 adults, every 5 kg/m 2 increase in BMI over 25 kg/m2 increases mortality by 30%. 1 Despite the OMS´s defnition as a disease, the large heterogeneity, of the “Obesity” deserves the qualifcation of a syndrome or “set of diseases” with diferent causes, pathophysiology and prognosis, but whose common feature is the excessive storage of fat. 2 Epidemiological data worldwide show the higher prevalence of obesity in women, and the trend seems to be increasing. 3 Many sociological and cultural factors have an infuence, but undoubtedly the role played by hormonal changes and emotional and psychological factors in women are enormously important, and they are often interrelated. Polycystic ovarian disease, thyroid disease, which are more prevalent in women, and the periods of adolescence, pregnancy and menopause are examples of situations that make susceptible women much more vulnerable to fat storage. Figure 1 Obesity-related chronic concomitant diseases in women.