n 373 © Europa Digital & Publishing 2013. All rights reserved. CLINICAL RESEARCH EuroIntervention 2013;9:373-381 DOI: 10.4244/EIJV9I3A60 *Corresponding author: Erasmus University Medical Center, Thoraxcenter, Department of Cardiology, Room Ba 559, ‘s-Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands. E-mail: r.vandomburg@erasmusmc.nl Health-related quality of life in the elderly three years after percutaneous coronary intervention Anna Panasewicz 1 , MD; Susanne S. Pedersen 1,2 , PhD; Stefanie J.G. Veenhuis 1 , MSc; Rohit M. Oemrawsingh 1 , MD; Wim J. van der Giessen †1 , MD, PhD; Robert-Jan van Geuns 1 , MD, PhD; Evelyn Regar 1 , MD, PhD; Peter P. de Jaegere 1 , MD, PhD; Patrick W. Serruys 1 , MD, PhD; Ron T. van Domburg 1 *, PhD 1. Department of Cardiology, Thoraxcenter, Erasmus Medical Center, Rotterdam, The Netherlands; 2. CoRPS - Center of Research on Psychology in Somatic diseases, Tilburg University, Tilburg, The Netherlands Abstract Aims: Long-term health-related quality of life (HRQOL) in the elderly after percutaneous coronary interven- tion (PCI) is unknown. We 1) compared HRQOL of elderly (≥70 years) with younger patients (<70 years) at 6, 12, 36 months post-PCI, and 2) examined whether predictors of impaired HRQOL 36 months post-PCI differed between older and younger patients. Methods and results: A prospective cohort of 651 PCI patients (26.3% ≥70 years) completed the SF-36 at 6, 12 and 36 months post-PCI. Older patients experienced a poorer physical HRQOL at all time points and worse mental HRQOL with respect to vitality and role emotional functioning (all p-values<0.05). By 36 months, the HRQOL for the older patients worsened in five of the eight subdomains (all p-values<0.05). Younger patients did not experience enduring changes in HRQOL, with the exception of role physical func- tioning. Predictors of impaired HRQOL were generally different for the elderly (diabetes, previous PCI) compared to younger cohorts (smoking, previous bypass surgery, ACE inhibitors), although poor six-month HRQOL, anxiety and depression were common predictors for both groups. Conclusions: Elderly PCI patients experience a deteriorating and poorer HRQOL than younger patients across three years. Contrary to younger patients, three-year HRQOL of elderly patients is irrespective of adverse events during outcomes. KEYWORDS • bare metal stent • drug-eluting stent • sirolimus-eluting stent