Chemistry and Materials Research www.iiste.org ISSN 2224- 3224 (Print) ISSN 2225- 0956 (Online) Vol.6 No.7, 2014 8 Assessment of Some Cardiac Biomarkers in Adult HIV Seropositives in Nnewi, Nigeria. Ifeoma Priscilla Ezeugwunne 1* , Charles Chinedu Onyenekwe 2 , Joseph Ebere Ahaneku 2 , Gladys Ahaneku 4 , Martins Ifeanyichukwu 3 , Samuel Chukwuemeka Meludu 1 , Rebecca Chinyere Chukwuanukwu 3 , Wuraola Serah Nnaemeka 1 , Okwara John Ekenedirichukwu 2 ,Okwudiri Nnadozie 5 ,Christian Ejike Onah 5 . 1. Department of Human Biochemistry; College of Health Sciences, Nnamdi Azikiwe University, Nnewi, Nigeria. 2. Department of Chemical Pathology; College of Health Sciences, Nnamdi Azikiwe University, Nnewi, Nigeria. 3. Department of Immunology, College of Health Sciences, Nnamdi Azikiwe University, Nnewi, Nigeria. 4. Department of Medicine, College of Health Sciences, Nnamdi Azikiwe University, Nnewi, Nigeria. 5. Department of Chemical Pathology; Nnamdi Azikiwe University teachim Nh Hospital, Nnewi, Nigeria. * Corresponding author, E-mail: goodnessifeoma007@yahoo.com The research is financed by Tertiary Educational Trust Fund (TETFUND), Nigeria. Abstract Human Immunodeficiency virus (HIV) infection is associated with increased of developing heart disease. Information on cardiac status in HIV infected in Nigerians is lacking. We assessed the impact of HIV infection on serum Myoglobin, Troponin, total CK, CK-MB, LDH and AST of HIV infected adults presenting at Nnamdi Azikiwe University Teaching Hospital Nnewi, Anambra State. The aim of this study is to determine some cardiac biomarkers in adult HIV seropositive participants, blood samples collected from the 300 randomly recruited participants were used for HIV screening, CD4 + T cell count, serum Myoglobin, Troponin, total CK, CK-MB, LDH and AST. Standard Laboratory methods were used for the analysis. The results showed that the mean serum Myoglobin and Troponin levels were significantly higher in symptomatic HIV participants not on antiretroviral therapy (ART) compared with asymptomatic HIV participants at P< 0.05, in each case. Also, the mean serum Myoglobin and Troponin levels were significantly higher in symptomatic HIV participants not on ART compared with HIV asymptomatic HIV participants at P<0.05 in each case. Again, the mean serum total Creatine kinase, CK-MB, LDH and AST were significantly higher in symptomatic HIV participants not on ART compared with asymptomatic HIV participants at P<0.05 respectively. Similarly, the mean serum total Creatine kinase, CK-MB, LDH and AST were significantly higher in symptomatic HIV participants not on ART compared with HIV seronegative control subjects at P<0.05 in each case. Once again, the mean serum total Creatine kinase, CK-MB and AST were significantly higher in asymptomatic HIV participants compared with HIV seronegative control subjects at P<0.05 respectively. Increased levels of some cardiac markers were seen in HIV infected participants. Keywords: HIV, cardiac markers, participants. 1 Introduction Human immunodeficiency virus (HIV) is a lentivirus that breaks down the body’s immune system, infects CD4 lymphocytes, depletes them and gradually leads to Acquired immunodeficiency syndrome (AIDS) which is a fatal illness (Rasool et al, 2008). Infection with HIV leads to a progressive impairment of cellular functions, which is characterized by a gradual decline in blood CD4 + T cell counts thereby predisposes the individual to a wide variety of opportunistic bacterial, fungal, viral, protozoal infections and cancerous growth (Khiangte et al, 2007). Reports have it that individuals infected with HIV have increased risk of developing cardiovascular diseases (Sudano et al, 2006) such as pericarditis (Sudano et al, 2006), endocarditis (Miro et al, 2003). There are some cardiac biomarkers used for measuring heart function especially in heart diseases (Vasadevan et al, 2011). In this study, cardiac protein markers such as Myoglobin, Troponin and cardiac enzyme markers such as total CK, CK-MB, LDH and AST were used to evaluate the cardiac function of adult HIV seropositives in Nnewi.