Eur Urol Suppl 2011;10(2):243 and correlated to upper urinary tract recurrence (UUTR). results: In group I (117/176 patients) one infltrated ureter could be seen (0.85%). On the contrary out of the 59/176 patients of group II 21 had a tumour involvement of the ureter (35.8%). This difference was signifcant (p<0.0001). In both groups a total of 403 ureteral edges were analyzed (group I: 232, group II: 171). Among patients with TCC of the bladder (group I) FSA in 1/232 (0.4%) was false negative. In group II (CIS of the bladder) 5/171 FSA results in fve different patients were false-negative (2.9%). Overall 2/176 patients (1.1%) had upper urinary tract recurrence during follow-up. Both patients had CIS of the bladder (group II). Of these two patients one had a dysplasia in the remnant ureter the other a CIS. Conclusions: (1) Patients who undergo RC because of a solitary or concomitant CIS of the bladder are at a signifcant increased risk of tumour involvement of the ureter. (2) FSA as intraoperative analysis can be regarded as accurate. (3) Patients with tumour-involved ureters and especially left positive margins are at a higher risk of upper urinary tract recurrence. 764 uPPer traCt reCurrenCes after CysteCtoMy – the PrognostiC value of M-fish Gruschwitz T. 1 , Tanovic E. 1 , Gajda M. 2 , Wunderlich H. 1 , Grimm M.O. 1 , Junker K. 1 1 University Hospital, Dept. of Urology, Jena, Germany, 2 University Hospital, Dept. of Pathology, Jena, Germany introduction & objectives: Patients after cystectomy for bladder cancer are at lifelong risk of oncological recurrence in the upper urinary tract. But, after cystectomy, only 2-6% of patients develop upper tract recurrence. The purpose of our study was to evaluate the prognostic value of Multicolor-Fluorescence In Situ Hybridisation to identify patients with increased risk of upper urinary tract recurrence after cystectomy. Materials & Methods: Washings of the upper urinary tract were done at time of cystectomy and were analysed by FISH according to established protocols for Urovysion®. 58 patients with transitional cell carcinoma of the bladder were evaluated, ureteral R1-situations were excluded. For comparison, 15 patients at time of prostatectomy because of prostate cancer were evaluated as well. Table 1: TNM-classifcation and -grading after cystectomy. T-Stadium pTa pT1 pT2 pT3 pT4 pCIS 2 16 16 17 6 1 Grading G1 G2 G3 G4 CIS 2 13 38 4 1 results: None of the 15 patients with prostatectomy had positive FISH results. 25/58 patients with bladder cancer had positive FISH results. After a median follow-up of 25 months, up to now three patients with positive FISH were identifed with upper tract recurrence after cystectomy whereas none of the 33 patients with negative FISH developed upper tract recurrence (12% vs. 0%). Therefore, patients with positive FISH are at considerable higher risk of tumour recurrence in the upper urinary tract already at time of cystectomy. Conclusions: FISH may be a promising non invasive tool in detection of patients with increased risk of upper tract recurrence at time of cystectomy. These selected patients should be monitored very intensive in the follow-up to detect tumours before symptoms develop and prognosis gets worse. 765 the fgfr3 Mutation identifies Patients with favorable disease at radiCal CysteCtoMy for bladder CanCer Van Rhijn B.W.G. 1 , Bostrom P.J. 1 , Shariat S.F. 2 , Finelli A. 1 , Sagalowsky A.I. 2 , Fleshner N.E. 1 , Bapat B. 3 , Kortekangas H. 4 , Ashfaq R. 5 , Mirtti T. 6 , Jewett M.A.S. 1 , Lotan Y. 2 , Van Der Kwast Th.H. 7 , Zlotta A.R. 1 1 University Health Network, Dept. of Urology, Toronto, Canada, 2 UT South- Western, Dept. of Urology, Dallas, United States of America, 3 Mount Sinai Hospital, Dept. of Cancer Genetics, Toronto, Canada, 4 University of Turku, Dept. Pathology, Turku, Finland, 5 UT South-Western, Dept. of Pathology, Dallas, United States of America, 6 University of Turku, Dept. of Urology, Turku, Finland, 7 University Health Network, Dept. of Pathology, Toronto, Canada introduction & objectives: Radical cystectomy (RC) is the standard treatment for patients with treatment-refractory non-muscle invasive (NMI) and for muscle invasive (MI) bladder cancer (BC). The FGFR3 mutation has gained attention as a marker for favorable NMI-BC and it was found to be associated with favorable prognosis. We determined the FGFR3 mutation status in a cohort of patients who underwent RC and evaluated its potential as a marker for favorable disease. Materials & Methods: We included 290 patients from three university hospitals who underwent radical cystectomy with at least a bilateral pelvic lymph-adenectomy. Patients who received neo-adjuvant treatment were excluded. All cases were reviewed by one uro-pathologist. FGFR3 mutation status was examined by multiplex PCR-SNaPshot analysis in the 290 cystectomy specimens and in 68 of 92 cancer-positive nodes. FGFR3 mutation status was correlated to various clinical and pathological parameters using chi-square statistics. results: A FGFR3 mutation was detected in 37 (13%) of RCs. Sixty-two patients were female. The mean age at RC was 65.5 years (range: 39-88 yrs). Pathological stage was <pT2, pT2, pT3 and pT4 in 48, 84, 120 and 38 RCs, respectively. Grade 2 (WHO1973) was found in 64 cases and Low-grade (WHO2004) in 24 cases. The remainder of the RCs were G3 and/or High-grade. Carcinoma in situ (CIS) and lympho-vascular invasion (LVI) were found 133 (46%) and 138 (48%) times, respectively. In 92 (32%) RC, positive lymph-nodes (N1=30, N2=62) were found. The median number of removed nodes was 13 (range: 1-53). Positive surgical margins were found at the bladder in 10, at the ureter in 7 and at the urethra in 6 cases. The presence of a FGFR3 mutation was associated with lower stage (P<0.001), lower grade (P<0.001), absence of CIS (P=0.005), absence of LVI (P=0.001) and pN0 (P=0.003). We found no correlation for the FGFR3 mutation to gender or margin status. We found a FGFR3 mutation in 2 out of 68 analyzed positive nodes. The same mutation was detected in the RC specimen. Conclusions: The FGFR3 mutation selectively identifes patients with favorable BC at RC. The mutation was extremely rare in patients with cancer-positive nodes. FGFR3 mutation status is a promising marker to guide decision making on adjuvant therapy after RC. 766 what do Patients feel about the inforMation Provision and suPPort with deCision Making Prior to CysteCtoMy and urinary diversion (ud) surgery and does it Correlate with their Quality of life (Qol) Post-surgery: results froM a ProsPeCtive study Somani B.K. 1 , Gimlin D. 2 , Fayers P. 3 , N'Dow J. 1 1 University of Aberdeen, Dept. of Urology, Aberdeen, United Kingdom, 2 University of Aberdeen, Dept. of Sociology, Aberdeen, United Kingdom, 3 University of Aberdeen, Dept. of Applied Health Sciences, Aberdeen, United Kingdom introduction & objectives: Urinary diversion is performed on the diseased or malignant bladder by either incontinent or continent diversion method. Our aim was to ask patients about the information provided to them and help/support received towards decision making prior to surgery. We also prospectively evaluate the QoL of these patients undergoing urinary diversion pre and 9-12 months post surgery. Materials & Methods: Thirty patients completed the information provision and decision making questionnaire relating to surgery. The questions included the quality of care, consultation time and information provided by the doctor. We also asked who had most infuence on the decision of cystectomy and whether they were satisfed with their involvement in making this decision and if all the questions were satisfactorily answered. QoL was measured prospectively using SEIQoL-DW, EORTC QLQ -30, EORTC BLM-30 and SWLS, pre and 9-12 months post surgery. results: All patients were happy with their decision and degree of involvement for UD surgery (Table). Of the 27 patients who had questions regarding the surgery, 25 got a satisfactory answer for all of their questions. Regarding the infuence on decision making for surgery, majority (22/30) felt that it was equally shared with the doctor. There was no difference in the QoL pre and post-surgery using SEIQoL- DW, EORTC QLQ- C30 and SWLS questionnaire. (1=Strongly agree; 2=Agree; 3=Neutral; 4=Disagree; 5=Strongly disagree) N Min Max Mean S D I did not feel that I was supported by the doctor 30 3 5 4.67 .547 I felt reassured by the doctor 30 1 3 1.57 .626 The doctor addressed all my questions and concerns 30 1 3 1.70 .651 The doctor took his/her time and listened to me 30 1 3 1.57 .626 The doctor asked for my opinion 30 1 4 1.93 .828 I felt hurried into the decision 30 4 5 4.47 .507 The doctor gave me all the information I needed to make the decision 30 1 3 1.60 .563 I thought carefully about the advantages and disadvantages of having the bladder surgery 30 1 4 1.70 .794 Conclusions: Patients felt supported and reassured from the doctor with all necessary information required for the surgery. Pre-operative patient involvement in the informed decision making and in urinary diversion surgery helps in preserving patients’ QoL post surgery. 767 Psa and funCtional outCoMe in a ConteMPorary Cohort of Patients subMitted to PotenCy sParing radiCal CysteCtoMy Puppo P., Introini C., Germinale G., Naselli A. National Institute for Cancer Research, Dept. of Urology, Genoa, Italy