Accepted Manuscript New Benzimidazothiazole Derivatives as Anti-inflammatory, Antitumor active agents: Synthesis, In-vitro and In-vivo Screening and Molecular Modeling Studies Mohamed M. El-Kerdawy, Mariam A. Ghali, Sara A. Darwish, Hatem A. Abdel- Aziz, Ahmad R. Elsheakh, Rehab S. Abdelrahman, Ghada S. Hassan PII: S0045-2068(18)30674-6 DOI: https://doi.org/10.1016/j.bioorg.2018.10.048 Reference: YBIOO 2582 To appear in: Bioorganic Chemistry Received Date: 7 July 2018 Revised Date: 21 October 2018 Accepted Date: 23 October 2018 Please cite this article as: M.M. El-Kerdawy, M.A. Ghali, S.A. Darwish, H.A. Abdel-Aziz, A.R. Elsheakh, R.S. Abdelrahman, G.S. Hassan, New Benzimidazothiazole Derivatives as Anti-inflammatory, Antitumor active agents: Synthesis, In-vitro and In-vivo Screening and Molecular Modeling Studies, Bioorganic Chemistry (2018), doi: https://doi.org/10.1016/j.bioorg.2018.10.048 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.