590 CONCLUSIONS: Both CRA and CRB showed similar strength gains in legs but CRA helped to increase strength in back, considering that energy and protein intake for players in CRA group decreased and they still had a significant increase in strength. Table 1. Strength and nutritional variables compared by group (CRB vs CRA) and by time (PRE vs POST) PRE POST p CRB by time p CRA by time CRB CRA p group CRB CRA p group Strength Biceps 37 ±4 35 ±4 0.49 38 ±3 36 ±4 0.50 0.42 0.68 Back 99 ±19 93 ±14 0.55 97 ±18 102 ±13 0.58 0.75 0.05 Legs 85 ±16 85 ±12 0.88 104 ±17 100 ±7 0.60 0.04 0.02 Right forearm 43 ±8 44 ±6 0.86 43 ±6 42 ±6 0.80 0.62 0.28 Left forearm 42 ±7 40 ±7 0.73 41 ±6 39 ±6 0.31 0.68 0.72 Nutrition Kcal 3312 ±1137 3541 ±783 0.65 2558 ±428 2793 ±813 0.51 0.10 0.02 CHO (g/ day) 479 ±181 443 ±86 0.64 359 ±85 345 ±79 0.73 0.09 0.07 Protein (g/day) 94 ±41 123 ±60 0.65 64 ±19 95 ±64 0.86 0.55 0.05 Fat (g/ day) 155 ±57 167 ±46 0.26 135 ±41 132 ±32 0.23 0.07 0.10 CH (g/ kg/day) 7.1 ±3 6.6 ±2 0.69 5.4 ±2 5.0 ±1 0.68 0.10 0.10 Protein (g/kg/ day) 1.4 ±1 1.9 ±1 0.79 0.9 ±0.3 1.4 ±1 0.94 0.49 0.07 Fat (g/ kg/day) 2.3 ±1 2.5 ±1 0.33 2.0 ±0.5 1.9 ±1 0.56 0.07 0.10 2385 Board #221 June 1 11:00 AM - 12:30 PM Chronic (24 weeks) Beta-alanine Supplementation Does Not Affect Muscle Taurine Or Blood Clinical Chemistry Bryan Saunders 1 , Mariana Franchi 1 , Luana F. Oliveira 1 , Vitor S. Painelli 1 , Vinicius E. Silva 1 , Rafael P. Silva 1 , Luiz A.R. Costa 1 , Craig Sale, FACSM 2 , Roger C. Harris 3 , Hamilton Roschel 1 , Guilherme G. Artioli 1 , Bruno Gualano 1 . 1 University of Sao Paulo, Sao Paulo, Brazil. 2 Nottingham Trent University, Nottingham, United Kingdom. 3 Junipa Ltd, Newmarket, United Kingdom. Reported Relationships: B. Saunders: Salary; Natural Alternative Inc.. PURPOSE: To investigate the effects of chronic beta-alanine (BA) supplementation on muscle taurine content, blood clinical markers and sensory side-effects. METHODS: Twenty-five healthy male participants (age 27 ± 4 y, height 1.75 ± 0.09 m, body mass 78.9 ± 11.7 kg) were supplemented with 6.4 g·day -1 of sustained release BA (N = 16; CarnoSyn TM , NAI, USA) or placebo (PL; N = 9; maltodextrin) for 24 weeks. Muscle biopsies of the m. vastus lateralis were taken at 0, 12 and 24 weeks and analysed for taurine content using high-performance liquid chromatography. Resting venous blood samples were taken in the supine position every 4 weeks and analysed for markers of renal, hepatic and muscle function (aspartate transaminase; alanine aminotransferase; alkaline phosphatase; lactate dehydrogenase; albumin; globulin; creatinine; estimated glomerular filtration rate and creatine kinase). Data were analysed using mixed model ANOVA. RESULTS: There were no significant differences in taurine content at Week 0 (BA: 33.67 ± 8.18 mmol·kg -1 dm, PL: 27.75 ± 4.86 mmol·kg -1 dm; p = 0.21). There was a significant main effect of group (p = 0.04) on muscle taurine, with overall lower values in PL, although there was no main effect of time or interaction effect (both p > 0.05; BA, Week 12: 35.93 ± 8.79 mmol·kg -1 dm and Week 24: 35.42 ± 6.16 mmol·kg -1 dm; PL, Week 12: 27.67 ± 4.75 mmol·kg -1 dm and Week 24: 31.99 ± 5.60 mmol·kg -1 dm). There was no effect of treatment, time or any interaction effects on any blood marker (all p > 0.05) and no self-reported side effects in these participants throughout the study. CONCLUSION: The current study showed that twenty-four weeks of BA supplementation at 6.4 g·day -1 did not affect muscle taurine content, clinical markers of renal, hepatic and muscle function, nor did it result in chronic sensory side-effects, in these healthy individuals. Since athletes are likely to engage in chronic supplementation, these data provide important evidence to suggest that supplementation with BA at these doses for up to 24 weeks do not adversely affect these markers in healthy individuals. E-38 Free Communication/Poster - Ergogenic Aids II - Beetroot and Nitrates Friday, June 1, 2018, 7:30 AM - 12:30 PM Room: CC-Hall B 2386 Board #222 June 1 11:00 AM - 12:30 PM Sucrose But Not Nitrate Ingestion Reduces High-intensity Exercise-induced Gut Injury Kristin L. Jonvik 1 , Kaatje Lenaerts 1 , Joey SJ Smeets 1 , Jeroen Kolkman 2 , Luc JC van Loon 1 , Lex B. Verdijk 1 . 1 Maastricht University, Maastricht, Netherlands. 2 Medisch Spectrum Twente and University Medical Center, Groningen, Netherlands. (Sponsor: Professor Janice L Thompson, PhD, FACSM) (No relevant relationships reported) PURPOSE: During high-intensity exercise many athletes suffer from gastrointestinal (GI)complaints, which are likely related to splanchnic hypoperfusion, resulting in intestinal injury. Intestinal perfusion may be improved by increasing circulating nitric oxide (NO) levels or inducing postprandial hyperemia, potentially attenuating intestinal injury during exercise. Therefore we investigated the effects of both dietary nitrate and sucrose ingestion on splanchnic perfusion and intestinal injury induced by high-intensity exercise. METHODS: In a randomized cross-over manner, 16 well-trained male athletes (age: 28±7 y; Wmax: 5.0±0.3 W·kg -1 ) cycled 60 min at 70% Wmax following acute ingestion of: sodium nitrate (NIT; 800 mg NO 3 ), sucrose (SUC; 40 g) or water placebo (PLA). Splanchnic perfusion was assessed using gastric air tonometry. Plasma intestinal fatty-acid binding protein (I- FABP) concentrations, reflecting enterocyte damage, were assessed every 20 min during and up to 60 min post-exercise. RESULTS: The exercise protocol resulted in hypoperfusion, as gap g-a pCO 2 levels increased during exercise (P<0.001), with no differences between treatments (P=0.47 for time x treatment interaction). Although plasma I-FABP concentrations increased during and post-exercise for all treatments (P<0.001), the increase was attenuated following SUC (P=0.007 for time x treatment interaction). In accordance, total I-FABP area under curve (AUC) tended to be different between treatments ( P=0.061), and I-FABP AUC was significantly Copyright © 2018 by the American College of Sports Medicine. Unauthorized reproduction of this article is prohibited.