 Corresponding author: Philips Carel Perdana Faculty of Medicine Universitas Airlangga, Surabaya, Indonesia. Copyright © 2022 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0. Correlation of plasma blood glucose levels at hospitality with clinical severity of Ischemic stroke patients at neurology department RSUD Dr. Soetomo surabaya during the period of January 2019 – December 2020 Philips Carel Perdana 1, * , Mohammad Saiful Ardhi 2 and Hermawan Susanto 3 1 Medical Program, Faculty of Medicine Universitas Airlangga, Surabaya, Indonesia. 2 Department of Neurology, Faculty of Medicine Universitas Airlangga, Surabaya, Indonesia. 3 Department of Internal Medicine, Faculty of Medicine Universitas Airlangga, Surabaya, Indonesia. World Journal of Advanced Research and Reviews, 2022, 15(02), 069–075 Publication history: Received on 27 June 2022; revised on 31 July 2022; accepted on 02 August 2022 Article DOI: https://doi.org/10.30574/wjarr.2022.15.2.0782 Abstract Stroke is one of the second most significant causes of death and the second highest cause of disability globally, 87% of which are ischemic strokes (IS). Blood glucose levels are known to have a relationship with the clinical outcome of IS patients as measured by the National Institutes of Health Stroke Scale (NIHSS). This study aims to determine the relationship between the patient's plasma blood glucose level upon hospital admission and the IS patient's severity. This research is a cross-sectional analytic study using medical records of IS patients hospitalized at the Neurology Department of RSUD Dr. Soetomo Surabaya between January 2019 and December 2020. Sampling was carried out using a total sampling technique, including patients with the diagnosis of an IS aged ≥18 years old. Patients with a diagnosis of ICH, SAH, TIA, and patients with a history of CHD were excluded from this study. We analyzed medical record data by Chi-Square statistical test on blood glucose and clinical outcomes of patients with NIHSS. In total, 53 out of 89 medical records met the inclusion criteria. Random; fasting; and 2 hours post-prandial blood glucose levels on IS patients in admission to the hospital showed a non-significant relationship with p=0.764; p=0.130; p=0.210 (p>0.05) with a weak correlation value to the clinical severity of patients as measured by NIHSS. Blood glucose levels at hospital admission cannot be the sole predictor in determining the clinical severity of IS patients using the NIHSS. Many other co-factors affect the clinical severity of the patient. Keywords: Admission blood glucose; Ischemic stroke; Ischemic stroke outcome; National Institutes of Health Stroke Scale (NIHSS) 1. Introduction Stroke is one of the second most significant causes of death after ischemic heart disease and the second highest cause of disability worldwide [1]. Stroke occurs due to blockage or rupture of brain blood vessels, resulting in cell/tissue death due to a lack of blood supply that carries oxygen to the brain [2]. Stroke is divided into two types based on pathology, ischemic stroke and hemorrhagic stroke. Ischemic stroke is an episode of neurological dysfunction in which there is damage to the brain and spinal cord due to a focal infarct in the brain, spinal cord, or retina [3]. 87% the most prevalence of stroke is ischemic stroke. In comparison, the majority of hemorrhagic strokes is 13%, further divided into 10% ICH and 3% SAH strokes [4]. One of the way to prevent and control stroke is to modify the risk factors for stroke itself. Risk factors for stroke include hypertension, diabetes mellitus, and high cholesterol levels [4]. Research conducted by [5] showed that an average high