Citation: Debatosh Paul, Amit Kumar Pramanik, Sanchita Biswas, Joysree Das Joya, Shahana Khanam, Mohammad Tanvir Islam (2022). Evaluating Relationship between Platelet Count, Leukocytes and Platelet Indices in Dengue Fever in a Tertiary Care Hospital in Bangladesh: A Retrospective Study. Saudi J Med, 7(5): 290-296. 290 Saudi Journal of Medicine Abbreviated Key Title: Saudi J Med ISSN 2518-3389 (Print) | ISSN 2518-3397 (Online) Scholars Middle East Publishers, Dubai, United Arab Emirates Journal homepage: https://saudijournals.com Original Research Article Evaluating Relationship between Platelet Count, Leukocytes and Platelet Indices in Dengue Fever in a Tertiary Care Hospital in Bangladesh: A Retrospective Study Debatosh Paul 1 , Amit Kumar Pramanik 2* , Sanchita Biswas 3 , Joysree Das Joya 4 , Shahana Khanam 5 , Mohammad Tanvir Islam 6 1 Professor and Chairman, Department of Laboratory Medicine, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh 2 Medical Officer, Department of Transfusion Medicine, Rajshahi Medical College Hospital, Rajshahi, Bangladesh 3 Lecturer, Department of Community Medicine, Dhaka National Medical College, Dhaka, Bangladesh 4 Clinical Pathologist, Shaheed Suhrawardy Medical College Hospital, Dhaka, Bangladesh 5 Resident, Department of Laboratory Medicine, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh 6 Associate Professor, Department of Internal Medicine, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh DOI: 10.36348/sjm.2022.v07i05.009 | Received: 21.04.2022 | Accepted: 18.05.2022 | Published: 24.05.2022 *Corresponding Author: Amit Kumar Pramanik Medical Officer, Department of Transfusion Medicine, Rajshahi Medical College Hospital, Rajshahi, Bangladesh Abstract Dengue fever is public health concerns in Bangladesh, where it occurs in epidemics and has a high mortality in the advanced stages. Clinical features are nonspecific and diagnosis is supported by lab features. Common lab tests include Platelet count, leucocyte count and platelet indices are useful in small rural set ups for early diagnosis and prognosis of dengue. The aim of this study is to evaluate relationship between platelet count, leukocytes and platelet indices. This retrospective cross-sectional study was conducted at Department of Laboratory Medicine in collaboration with Department of Internal Medicine, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh from July 2019 to September 2019. Clinical records of 260 cases were preserved in a structured Clinical Record Form (CRF). Only those, with antigen/antibody supported cases was enrolled in the study. Mean neutrophil (%), mean lymphocyte (%) and mean eosinophil (%) count were statistically significant difference among different platelet count groups (p<0.05). There was significant negative correlation between PDW and platelet count (r= -0.228, p<0.001). MPV was also negatively correlated with platelet count but not significant (r= -0.106, p= 0.088). Beside Platelet count and leukocyte count, Platelet indices such as PDW and MPV are also useful to monitor dengue fever. Keywords: Dengue Fever, Platelet count, Leukocyte, Platelet Indices. Copyright © 2022 The Author(s): This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International License (CC BY-NC 4.0) which permits unrestricted use, distribution, and reproduction in any medium for non-commercial use provided the original author and source are credited. 1. INTRODUCTION Dengue is emerging as a serious public health problem globally. It is estimated to occur annually in over 100 endemic countries, putting almost half of the world's population at risk [1, 2]. The incidence and geographical distribution of dengue infections have significantly increased in the past few decades and a large number of cases remain undiagnosed and underreported. The overall incidence of dengue having increased 30-fold over the past 50 years [3]. Most of the cases are reported from Southeast Asia and the western Pacific regions. Southeast Asian region together with Western Pacific region bears nearly 75% of current global disease burden [4]. Dengue fever is the most common arthropod borne disease caused by dengue virus. It is a vector borne arboviral disease transmitted by predominantly by Aedes aegypti and Aedes albopictus mosquito. Man and mosquito are reservoir of the infection [5]. Increases in the incidence of dengue outbreaks are seen during the monsoon and post- monsoon seasons. Children and young adults are the population that are most affected [6]. Early, accurate diagnosis and an accurate assessment of the stage and condition of the patient are very important factors in determining the patient's prognosis. The more severe the patient's disease, the worse the prognosis [7, 8]. Bleeding is usually caused by thrombocytopaty and thrombocytopenia, therefore it is necessary to check