Graphical Abstract Preparation of penta-azole containing cyclopeptides: challenges in macrocyclization D. Hernández, E. Riego, A. Francesch, C. Cuevas, F. Albericio,* M. Álvarez * Barcelona Science Park, Josep Samitier 1-5, E-08028 Barcelona, Spain O S N CO 2 Me O N N O N O N Ph NHBoc Ot-Bu 3 O S N NHBoc MeO 2 C HN O O HN O N N O N O N Ph t-BuO O S N R H N N H O O NHBoc CO 2 Me O N N O N O N Ph 1 2 Leave this area blank for abstract info. Create PDF files without this message by purchasing novaPDF printer (http://www.novapdf.com)