Asian Journal of Medical Research ¦ Volume 9 ¦ Issue 1 ¦ January-March 2020 1 Section: Radiation Oncology Malignant Melanoma of Small Bowel: A Rare Case Kamal Bandhate 1 , Ashok Kumar Diwan 2 , Subeera Khan 3 1 Post Graduate, Department of Radiation Oncology, Govt. Medical College & Hospital Nagpur, India, 2 Prof. & Head, Department of Radiation Oncology, Govt. Medical College &Hospital, Nagpur, 3 Senior Resident, Department of Radiation Oncology, Govt. Medical College & Hospital, Nagpur. Melanomas affecting the small bowel are usually metastasis from primary cutaneous lesions. A primary melanoma of the gastrointestinal tract is very rare with reported incidence of just 3%. We present a case of small bowel melanoma with liver metastases. Primary malignant melanoma of the small intestine is quite rare with only a few cases reported in literature. Like its cutaneous counterpart, intestinal melanomas too remains an aggressive disease with a poor prognosis. The overall survival of malignant melanoma affecting the GI tract is 4 to 6 months with a survival rate of less than 10% at 5 years. Keywords: Malignant Melanoma, Gastro Intestinal Tract, Small Bowel, Liver Metastases. Corresponding Author: Dr. Ashok Kumar Diwan, Professor and Head, Department of Radiation Oncology, Govt. Medical College &Hospital, Nagpur, Maharashtra, India. Received: January 2020 Accepted: January 2020 Introduction Malignant melanoma develops from melanocytes which are usually located in the skin, the eye’s choroid, the meninges, and the anal margin. Melanoma of the GI tract represents 1 to 3% of the digestive tract cancers. [1] Primary malignant melanoma of the small intestine is quite rare, only a handful of cases have been reported in literature. Like its cutaneous counterpart, intestinal melanoma too remains an aggressive disease with a poor prognosis. The survival of patients with melanoma affecting the GI tract is 4 to 6 months with an overall survival rate of less than 10% at 5 years. [1] Case Report Figure 1: H & E Stained Slide We present a rare case report of a 48 year old man who presented with pain in abdomen and weight loss. He already had underwent an ultrasound of the abdomen which was suspicious of liver metastases, before being referred to our side for further management. Figure 2: S-100 Investigations: • Contrast Enhanced CT scan of the abdomen and pelvis ISSN (0): 2347-3398; ISSN (P): 2277-7253