ResearchArticle Physiological Gingival Melanin Hyperpigmentation Treatment with Injectable Vitamin C and Scalpel Technique: A Randomised Controlled Clinical Trial Dhanashree S. Chaudhary , 1 Simran R. Parwani , 1 Shital Barkhade, 1 Minal Gajbhiye, 1 Rajkumar Parwani , 2 Geetanjali Sikka , 3 Kshipra Kawadkar , 1 Nishita Jaju Soni, 1 Niccol ` o Giuseppe Armogida , 4 Himanshu Dadlani , 5,6 and Gianrico Spagnuolo 4,7 1 epartment of Periodontology, V.Y.W.S. ental College and Hospital, Amravati, Maharashtra 444602, India 2 epartment of Oral Pathology, V.Y.W.S. ental College and Hospital, Amravati, Maharashtra 444602, India 3 epartment of Periodontology, Eklavya ental College & Hospital Kotpulti, Rajasthan 303108, India 4 epartment of Neurosciences, Reproductive and Odontostomatological Sciences, University of Naples Federico II, Naples80131,Italy 5 epartment of Periodontology, Kalka ental College, Meerut 250002, India 6 Kalka ental College, Meerut 250016, India 7 Terapeutic entistry epartment, Institute for entistry, Sechenov University, Moscow 119991, Russia Correspondence should be addressed to Gianrico Spagnuolo; gspagnuo@unina.it Received 4 October 2022; Revised 3 January 2023; Accepted 4 January 2023; Published 18 January 2023 AcademicEditor:DimitrisN.Tatakis Copyright © 2023 Dhanashree S. Chaudhary et al. Tis is an open access article distributed under the Creative Commons AttributionLicense,whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkis properly cited. Harmonybetweenfacialcomplexionandgingivalhealthgoeshandinhand.Gingivaldepigmentationisanaestheticcorrectionof hyperactivemelanocytesingingivaltissuesthatleadtohyperpigmentation.Currentstudycomparesdepigmentation,painscores, and itching with scalpel technique and nonsurgical intramucosal Vitamin C injection. 30 individuals in the age range of 18–40years conscious of dark gums were randomly allocated to test and control group by lottery method. Torough Phase I therapywasperformedoneweekbeforetheprocedure.Areaandintensityofdepigmentationwereevaluatedpreoperativelyand postoperatively; pain score, itching, and repigmentation percentage were the postoperative parameters. After 24hrs, test group showed signifcantly lesser VAS score for pain as compared to control group. Tere was no statistically signifcant diference in preoperativeareaofpigmentationbetweenthetestandcontrolgroup(p � 0.936).Postoperativelyalso,therewasnostatistically signifcantdiferenceinareaofpigmentationbetweenthetestandcontrolgroup(p � 0.932).Forcomparingareaofpigmentation, an independent t•test was applied and Mann–Whitney test was used for diferentiating the intensity of pigmentation, repig• mentation,andVASscorebetweenthegroups.TestudyconcludedthatVitaminCmesotherapyandscalpeltechniqueshowed comparable results in reduction of areas and intensity of gingival hyperpigmentation. 1. Introduction Over the last decade, an exponential request of aesthetic treatments has been increasingly observed, especially in the dentistry feld. In fact, having an aesthetically satisfying smile playsanimportantroleinthepsychologicalwellbeingandself• confdence. Tere are various factors that determine the overall aestheticofsmiledesignsuchaslipcompetency,lipline,gums, and teeth morphology [1]. Te aesthetic of the gingival tissues, also known as the pink aesthetic, can greatly infuence the overall clinical appearance of the smile. Regardless of the color ofthegingivaltissueswhichmayphysiologicallyvaryfrompale pink to bluish purple [2], gingival pigmentations may alter and impact the pink aesthetic. Gingival hyperpigmentation can be Hindawi International Journal of Dentistry Volume 2023, Article ID 4586923, 8 pages https://doi.org/10.1155/2023/4586923