ORIGINAL ARTICLE Bali Medical Journal (Bali Med J) 2020, Volume 9, Number 1: 286-290 P-ISSN.2089-1180, E-ISSN.2302-2914 286 Open access: www.balimedicaljournal.org and ojs.unud.ac.id/index.php/bmj CrossMark Published by DiscoverSys ABSTRACT Background: Obesity is a state of Body Mass Index (BMI) above or equal to 25 kg/m2. In obesity, dyslipidaemia can occur alone or together with other comorbid. This situation could afect pro- infammatory and anti-infammatory cytokines that lead to health problems. Several parameters assessed in dyslipidaemia conditions include High-Density Lipoprotein (HDL) and adiponectin. This study aims to evaluate the correlation between HDL and adiponectin levels in obese adolescents. Methods: A cross-sectional observational study was conducted among 33 obese adolescence (0-18 years) who met the inclusion criteria at Junior and Senior High School in Denpasar during August 2018-January 2019 period. Variables evaluated in this study were age, sex, weight, height, BMI, HDL, and adiponectin. The correlation assessment of HDL and adiponectin levels was conducted by Partial Correlation test after controlling age and sex using SPSS version 23 for Windows. Results: Males (66.70%) were predominant than females (33.30%) with a ratio of 2: 1. The average age of respondents was 15.51± 0.70 years old. The mean body weight was 91.04±15.40 kilograms, followed by height (163.09±7.40 cm), BMI (34.08±3.90 kg/m 2 ), HDL (43.40±8.00 mg/dl), and adiponectin (4.55±2.1 µg/ml). There was a very weak and not signifcant correlation by Partial correlation test (r=0.143; p=0.444) between HDL and adiponectin levels. Conclusion: Our study found There was a very weak and not signifcant correlation between HDL and adiponectin levels among obese adolescent in Denpasar, Bali, Indonesia. Keywords: Obese, Adolescents, HDL, Adiponectin Cite This Article: Wahyuni, N.L.G., Arimbawa, I.M., Kardana, I.M., Suarta, K., Artana, I.W.D., Adnyana, I.G.A.N.S. 2020. The correlation of High- Density Lipoprotein (HDL) with adiponectin levels among obese adolescents in Denpasar, Bali, Indonesia. Bali Medical Journal 9(1): 286-290. DOI: 10.15562/bmj.v9i1.1630 The correlation of High-Density Lipoprotein (HDL) with adiponectin levels among obese adolescents in Denpasar, Bali, Indonesia Ni Luh Gede Wahyuni, 1 I Made Arimbawa, 2* I Made Kardana, 2 Ketut Suarta, 2 I Wayan Dharma Artana, 2 I Gusti Agung Ngurah Sugitha Adnyana 2 INTRODUCTION Te number of obese adolescents is increasing notably in morbidity due to obesity such as meta- bolic syndrome which is characterized by the occurrence of dyslipidaemia. 1 Dyslipidaemia is an imbalance of lipid profle, namely increased levels of triglycerides (TG), Low-Density Lipoprotein (LDL), total cholesterol (TC), and decreased levels of High-Density Lipoprotein (HDL). 2 In dyslipi- daemia, an infammatory process occurs, which increases pro-infammatory cytokines and suppres- sion of anti-infammatory cytokines. 3 One of the anti-infammatory cytokines is adipocytokines in adipose tissue, adiponectin. Adiponectin levels are associated with HDL levels, abdominal fat index, body mass index (BMI) and insulin sensitivity. 4 Obese adolescents are adolescents who have the condition, the BMI is at or above the 95th percen- tile on the CDC 2000 growth curve according to age and sex. 5 Obesity can occur at any age, but the most ofen occurs in the frst year of life, ages 5-6 years, and in adolescence.6 Te previous study showed that the prevalence of adolescents from 2010 was 1.4%, rising to 7.3% in 2013.6 Centres for Disease Control and Prevention (CDC) obtained data where the percentage of adolescents aged 12 to 19 years who are obese in the United States increased from 5% in 1980 to 21% in 2012. 4-6 Bali Province has an overweight and obesity prevalence above the national prevalence for adoles- cents aged 13-15 years and aged 16-18 years. 5 Te prevalence of obesity in Denpasar in 2002 was 11% in adolescents aged 11-17 years. 6 Te prevalence of obesity is 15% in children aged 10-12 years. 7 Obese adolescents have elevated TC levels, increased LDL values, decreased HDL values, increased levels of TG and TG: HDL ratio. 8 Adiponectin is one of the adipokines that are widely produced and secreted by adipose tissue and has anti-diabetic, anti-infammatory, anti-atherogenic, and cardio- protective efects. 9-11 In obesity conditions, there is an increase in pro-infammatory cytokines and a decrease in anti-infammatory cytokines. A study conducted by Hendarto A found that in obese adolescents found variations in adiponectin levels were low and normal, but no signifcant relation- ship was found between obesity and adiponectin 1 Pediatric Resident, Faculty of Medicine, Universitas Udayana, Sanglah General Hospital, Bali, Indonesia 2 Department of Child Health, Faculty of Medicine, Universitas Udayana, Sanglah General Hospital, Bali, Indonesia * Correspondence to: I Made Arimbawa; Department of Child Health, Faculty of Medicine, Universitas Udayana, Sanglah General Hospital, Bali, Indonesia; de_awae@yahoo.co.id Received: 2019-10-19 Accepted: 2020-02-11 Published: 2020-04-01