IP International Journal of Comprehensive and Advanced Pharmacology 2022;7(4):195–202 Content available at: https://www.ipinnovative.com/open-access-journals IP International Journal of Comprehensive and Advanced Pharmacology Journal homepage: https://www.ijcap.in/ Original Research Article Formulation and evaluation of nano-ethogel of silver sulfadiazine for treatment of topical burns Saloni Bhandari 1, *, Kamal Singh Rathore 1 1 Dept. of Pharmacy, Bhupal Nobles College of Pharmacy, B N University, Udaipur, Rajasthan, India ARTICLE INFO Article history: Received 23-08-2022 Accepted 15-09-2022 Available online 13-01-2023 Keywords: Ethosomes silver sulfadiazine Vesicular drug delivery system Nano-ethogel Burns In vitro drug release. ABSTRACT Introduction: The present study deals with the formulation of ethosomal suspension containing silver sulfadiazine, followed by its incorporation into a hydrogel, leading to the formulation of a novel vesicular nano-ethogel of silver sulfadiazine for the treatment of topical burns. Materials and Methods: Silver Sulfadiazine ethosomes were prepared by the hot method suggested by Elka Touitou. This ethosomal suspension was loaded into hydrogel made of Carbopol 934 in a ratio of 1:1. Carbopol 934 was chosen as a gelling agent as it do not cause any sort of skin irritation. The nanoethosomal formulations containing SSD were evaluated for their physical appearance, pH, spreadability, viscosity, extrudability, drug content. Result and Discussions: In vitro drug release studies were performed for five hours and it was observed that the formulation F4 had the maximum amount of drug released within duration of five hours i.e. 76.80%. The complete study wrap up that this ethosomal approach of silver sulfadiazine incorporated into a hydrogel provides an advance sustained and targeted delivery of silver sulfadiazine. This is an Open Access (OA) journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. For reprints contact: reprint@ipinnovative.com 1. Introduction Nanotechnology, often abbreviated as nanotech is referred to as imaging, designing, modeling, formulation, characterization, and application of structures by controlled modification of size and shape at the nanometer scale (1nm to 100nm), thereby, producing system with novel properties. Particles formulated in such a manner are termed as nanoparticles. 1 The ethosomes are vesicular carrier systems consisting of hydroalcoholic or hydro/alcoholic/glycolic phospholipid with relatively high alcoholic concentrations (Figure 1). Main components of ethosomes are phospholipids, ethanol (upto 45%), glycerol and water, which facilitate delivery of high concentration of active ingredients through skin. 2,3 * Corresponding author. E-mail address: salonibhandari1996.sb@gmail.com (S. Bhandari). As ethosomes are soft and malleable vesicles, they serve as potential carriers for drug transportation. Active drug permeation can be enhanced by acclimatizing due to efficacy, safety, and simplicity in their medication. Fig. 1: Structure of ethosome 4 https://doi.org/10.18231/j.ijcaap.2022.038 2581-5555/© 2022 Innovative Publication, All rights reserved. 195